Science Translational Medicine

A unique human challenge study illuminates how dengue immunity shapes the nature of repeated infections, researchers identify a targetable molecular driver of skin inflammation in psoriasis, and more this week in #ScienceTranslationalMedicine.

By applying a unique polyene scaffold, researchers engineer a next-generation, broad-spectrum #antifungal that selectively targets ergosterol without binding to cholesterol, avoiding severe toxicity linked to drugs like amphotericin B.

Researchers present a novel agent for near-infrared fluorescent imaging of #LungCancer that binds to ChoK-alpha, which can highlight close tumor margins and spot easy-to-miss lesions during surgical resection of tumors in canines. @PennRadiology

By parsing metabolic data from more than 18,000 participants in China, scientists have derived new “clock” models of metabolic #aging that incorporate novel metrics linked to higher chronic disease risk and all-cause mortality. @sjtu1896

An analysis of trial data from stem cell transplant recipients shows how immune suppression with either #cyclophosphamide or #tacrolimus shapes T cell reconstitution—and has opposing effects on the risk of #GVHD or infection post-transplant. @MSK_DeptOfMed

By applying a unique polyene scaffold, researchers engineer a next-generation, broad-spectrum #antifungal that selectively targets ergosterol without binding to cholesterol, avoiding severe toxicity linked to drugs like amphotericin B.

A new antifungal drug architecture combats infections in mice without the usual toxicity, a fluorescent imaging agent could enable more pinpointed removal of lung cancer tumors, and more in this week's new issue of #ScienceTranslationalMedicine.

AI is transforming the discovery and design of #antibiotics but requires concurrent progress in data standards, validation pipelines, and regulation to reach patients, argues a new Viewpoint. @delafuentelab @Hanqun_CAO @MIT_IMES

In a new Editorial, researchers sound the alarm against the rising tide of rifampicin-resistant #tuberculosis and urge the need for an effective vaccine and control measures that integrate genomics and social interventions. @Unesp_Oficial @facfarmaciaUL

A new Viewpoint discusses how integrating modernized commercial models, genomic surveillance, streamlined trial design, advances in #AI, and other innovations can tackle the dangers of #AntibioticResistance. @GSK

A small molecule therapy for #Alzheimers disease that activates #TREM2 in #microglia boosts the breakdown of amyloid-beta in neurons and mice and is well-tolerated in healthy individuals and patients, according to results from a phase 1 trial. @sanofi

A new Editorial stresses the importance of the simple but fundamental concept of prevention in combating antimicrobial resistance, and calls for more support for IPC and WASH in low- and middle-income countries to reduce antibiotic demand. @EdinUniUsher

With tests in mice, researchers identify a new drug candidate delivered as a single, low dose to treat #schistosomiasis infection across the parasite's lifespan.

Applying Fc engineering, researchers fashion potent bispecific antibodies against #SARSCoV2 that can be delivered via mRNA to target multiple viral epitopes and can constrain the virus’ ability to evade recognition. @moderna_tx

By parsing metabolic data from more than 18,000 participants in China, scientists have derived new “clock” models of metabolic #aging that incorporate novel metrics linked to higher chronic disease risk and all-cause mortality. @sjtu1896

The new issue of #ScienceTranslationalMedicine is out! A large clinical study in China uncovers "clocks" of human aging that may predict chronic disease, a new mRNA antibody therapy could better tackle ever-evolving SARS-CoV-2 variants, and more.

Moran Amit is the 2026 recipient of the #AAAS Martin and Rose Wachtel Cancer Research Award for his research on how cancer reprograms peripheral nerves to evade immunity—and how to target this relationship to support #immunotherapy. @UTMDAnderson

Gut bacteria such as Lactobacillus prime intestinal epithelial cells in newborn mice to produce the antimicrobial protein calprotectin, making them less susceptible to sepsis and infection-related death. @CincyChildrens

A topical combo of the mite-killing compound #flavesone and the ovicidal drug #abametapir quickly wipes out mites and eggs that cause #scabies with a single dose and cures infections more quickly than ivermectin in pigs. @QIMRB_Institute @DeepsDarshi

An invasion of immune cells from skull bone marrow triggers inflammation that drives cognitive and mood decline with age in adults with chronic #TBI, shows work that also identifies #fenofibrate as a promising therapy in a pilot trial.