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Hummer Lab

@HummerLab

Molecular simulations and computational biophysics @MPIbp

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  2. Hummer Lab@HummerLab
    Hummer Lab
    RT @MiChAeL_900922: Happy to share our latest study in @Nature revealing how FLVCR1 & FLVCR2 transport choline & ethanolamine, and shedding light on their roles in related rare diseases. Two in One! 🔬 Read more: Great teamwork with @SafarianSchara @HummerLab @nguyenln_ 💪
    0502.4K
  7. bioRxiv@biorxivpreprint
    Intrinsically disordered region amplifies membrane remodeling to augment selective ER-phagy #bioRxiv
    02167.5K
  9. Hummer Lab@HummerLab
    Hummer Lab
    RT @MPIbp: #ATP, the energy currency of cells, is produced by the mitochondrial protein ATP synthase. Our @HummerLab provides new insights into the structural mechanism and energetics of the crucial proton-driven c-ring rotation by atomistic free energy calculations👉
    02207.4K
  11. Hummer Lab@HummerLab
    Hummer Lab
    RT @TheHurleyLab: 🚨Now in print!🚨Sankalp Shukla @Sankalp Shukla_ in collaboration with @PIHanson lab and @HummerLab probes the mechanistic and cellular implications of direct membrane binding by the ESCRT and ERES associated Ca2+- sensor ALG- 2 protein. Read it: @PNASNews
    0705.8K
  12. Hummer Lab@HummerLab
    Hummer Lab
    RT @MPIbp: Video by S. Rao: All-atom molecular dynamics simulation of the membrane-recruited ATG12-ATG5-ATG16L1-WIPI2 complex loaded with the ATG3-LC3 conjugate. Congratulations to all authors from @LazarouLab, @TheHurleyLab and @HummerLab on this amazing publication in @ScienceAdvances!
    0202K
  13. Hummer Lab@HummerLab
    Hummer Lab
    RT @MPIbp: S.Rao from our @HummerLab & coworkers resolve mechanism of LC3 delivery to the phagophore membrane, a key step in selective #autophagy, by combining #MDsimulations & experiments. Three-step targeting of ATG12-ATG5-ATG16L1 machinery leads to LC3 lipidation👉
    088027.4K
  14. Hummer Lab@HummerLab
    Hummer Lab
    RT @MPIbp: Scientists from the MPI of Molecular Physiology (@mpimoph) and from our Department of Theoretical #Biophysics (@HummerLab) have identifed a region in actin that functions as a “molecular backdoor” for phosphate to exit through! 👉
    01205.4K
  15. Hummer Lab@HummerLab
    Hummer Lab
    RT @WoutOosterheert: Very excited that our manuscript is now online @NatureSMB! We show how actin filaments release inorganic phosphate (Pi) through a “molecular backdoor” and demonstrate that the backdoor is distorted in a disease-linked actin variant. A thread (1/17)
    032021.2K
  16. Hummer Lab@HummerLab
    Hummer Lab
    RT @TheHurleyLab: New preprint! @AutophaZeke’s PI3KC3-C1/RAB1A structure reveals that VPS15 is a GTP-binding pseudokinase that repurposes the kinase fold to regulate a myristoylation, and stabilize a large rotation in the VPS34 lipid kinase to promote membrane binding and PI(3)P synthesis!
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  17. Hummer Lab@HummerLab
    Hummer Lab
    RT @TheHurleyLab: The 2024 Gordon Conference on Autophagy will be held at the beautiful Il Ciocco site in Tuscany Mar. 10-15. If you have a passion for autophagy or just want to learn more, apply now before it gets oversubscribed!
    039019.4K
  18. Hummer Lab@HummerLab
    Hummer Lab
    RT @Beck_Laboratory: Detection of various complexes in cryo electron tomograms. Great work by @SergioCruzLeon1 and others now online. @MPIbp #teamtomo #cryoem @ChanZuckerberg
    Sergio Cruz-León @SergioCruzLeon1
    🧵[1/6] We achieve high-confidence localization of a wide range of macromolecular complexes, their subunits, and functional substates through 3D template matching (TM) for #CryoET. This allows us to capture vaults transporting ribosomal cargo in situ!🤯
    0204.4K
  19. Sergio Cruz-León@SergioCruzLeon1
    🧵[1/6] We achieve high-confidence localization of a wide range of macromolecular complexes, their subunits, and functional substates through 3D template matching (TM) for #CryoET. This allows us to capture vaults transporting ribosomal cargo in situ!🤯
    İndir
    45118937.4K
  20. Hummer Lab@HummerLab
    Hummer Lab
    RT @MPIbp: The role of CydDC, a potential target for new antibiotics, in the bacterial energy metabolism has remained nebulous for decades. Scientists from our Institute, @ALIFE_VU, @UGent, @UniKent solved the riddle: CydDC is a heme transporter👉 #biophysics #cryoEM
    0603.5K
  21. Hummer Lab@HummerLab
    Hummer Lab
    RT @okapik: So nice to see Gerhard @HummerLab in Okazaki!
    Ryota IINO 飯野亮太 @ryotaiino
    Prof. Gerhard Hummer (Max Planck Institute of Biophysics @MPIbp) gave a seminar at the 970th IMS colloquium and visited our lab with Kei-ichi @okapik! Thank you very much for great and thought-provoking seminar and discussion!
    0203.2K
  22. Ryota IINO 飯野亮太✓@ryotaiino
    Prof. Gerhard Hummer (Max Planck Institute of Biophysics @MPIbp) gave a seminar at the 970th IMS colloquium and visited our lab with Kei-ichi @okapik! Thank you very much for great and thought-provoking seminar and discussion!
    İndir
    01175.3K
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