Jan Philipp Kreysing@jpkreysing
I will from now on only be posting on bluesky @jpkreysing.bsky.social
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Jan Philipp Kreysing
@jpkreysing
PhD student - Cellular biophysics (cryo-ET) | @MPIbp @Beck_Laboratory @IMPRS_CBP
126 Following107 Followers39 Posts
- Jan Philipp Kreysing@jpkreysingSo happy that my main PhD project on HIV-1 nuclear entry is now out in Cell. I want to especially thank my supervisor Martin @Beck_Laboratory and our amazing collaborators @MaziarHeidari1 from @HummerLab, @VojtechZila from the Kräusslich lab and many others.Max Planck Institute of Biophysics @MPIbpFresh out of the press! ✨Check out our new paper on the violent entry of the HIV capsid into the nuclear pore — watch it crack that gate! 🤯 💥 Incredible work from @Beck_Laboratory and @HummerLab 🤩 More here: 🔗15241K
Fresh out of the press! ✨Check out our new paper on the violent entry of the HIV capsid into the nuclear pore — watch it crack that gate! 🤯 💥 Incredible work from @Beck_Laboratory and @HummerLab 🤩 More here: 🔗49236324.8K- Jan Philipp Kreysing@jpkreysingJan Philipp KreysingRT @Beck_Laboratory: … and perfect timing. Work by @HuaipengXing with @FrydmanLab out @Nature. PDCD5 binds virtually all open #TRiC, while closed TRiC forms clusters inside of cells. Congrats to all authors.0501.6K
- Jan Philipp Kreysing@jpkreysingJan Philipp KreysingRT @Beck_Laboratory: Did you know that nuclear pore complexes can turn up outside the nuclear envelope? Studying these, @JennySachweh, Bernhard Hampoelz and others uncover that the surrounding cellular milieu determines NPC composition via the nuclear transport system itself. #teamtomo #NPC A 🧵032019.3K
- Jan Philipp Kreysing@jpkreysingJan Philipp KreysingRT @SergioCruzLeon1: We are excited to announce the publication of high confidence 3D template matching for #cryoET @HummerLab @Beck_Laboratory @jpkreysing @geissler_katha @s_l_schaefer @pc_hoffmann @MPIbp @cziscience Paper's link: See it in action in our short video!038020.7K
- Jan Philipp Kreysing@jpkreysingJan Philipp KreysingRT @MPIbp: Check out now why thinner is not always better 👉 Congratulations on this fantastic work to the authors M. W. Tuijtel, @SergioCruzLeon1, @jpkreysing, @sonjawelsch, G. Hummer (@HummerLab), M. Beck (@Beck_Laboratory) and B. Turonova 🥳0501.2K
- Jan Philipp Kreysing@jpkreysingGreat systematic study by Maarten Tuijtel from our group on how FIB-lamellae properties can affect subtomogram averaging results. The main message is quite positive for anyone worried about lamella thickness and/or ion damage. #teamtomo @Beck_Laboratory @MPIbpbioRxiv @biorxivpreprintThinner is not always better: Optimising cryo lamellae for subtomogram averaging #bioRxiv106759
- Jan Philipp Kreysing@jpkreysingPosts @jpkreysing@Beck_Laboratory @MPIbp FIB-lamellae benchmarking study by Maarten Tuijtel et al. now out in Science Advances!19292.7K
- Jan Philipp Kreysing@jpkreysingCan highly recommend applying to this PhD program. I'm now in my third year here and couldn't be happier. @imprs_cbp @MPIbpIMPRS on Cellular Biophysics @imprs_cbpLooking for a #PhDposition in the #LifeSciences? #Apply to our #gradschool on cellular #biophysics! Prepare your documents & contact your referees. We look foward to get to know you👉 #imprs #phd @goetheuni @uni_mainz @fias_science @MPIbp @maxplanckpress0110625
- Jan Philipp Kreysing@jpkreysingPosts @jpkreysingThanks to all coauthors: @SergioCruzLeon1, @aobarska, @metavibor, @sonjawelsch, Jürgen Köfinger, Beata Turonova, and especially my joint first authors @MaziarHeidari1 and @VojtechZila. Also fantastic supervision by @Beck_Laboratory, @HummerLab, and Hans-Georg Kräusslich.215295
- Jan Philipp Kreysing@jpkreysingPosts @jpkreysingTemplate matching NPC ring subunits in cryo tomograms has emerged very recently thanks to works by @SergioCruzLeon1 and @Reiya_Tan1guch1 We can now look at the structures of individual NPCs and are no longer limited to averages.003158
- Jan Philipp Kreysing@jpkreysingVery happy that our work on HIV nuclear entry is now out as a preprint. Check out the thread for a summary. The most surprising finding was that the capsid appears to crack the NPC scaffold as revealed by cryo-ET and template matching. #teamtomoBeck Laboratory @Beck_LaboratoryIn a great collaboration with @HummerLab and the Kräusslich lab, @jpkreysing, @MaziarHeidari1, @VojtechZila and others tackle what happens when HIV capsid goes through an NPC. Instead of the NPC cracking the capsid, the capsid appears to crack the NPC (@MPIbp @CiidHeidelberg).14243K
- Jan Philipp Kreysing@jpkreysingJan Philipp KreysingRT @Beck_Laboratory: In a great collaboration with @HummerLab and the Kräusslich lab, @jpkreysing, @MaziarHeidari1, @VojtechZila and others tackle what happens when HIV capsid goes through an NPC. Instead of the NPC cracking the capsid, the capsid appears to crack the NPC (@MPIbp @CiidHeidelberg).030018.8K
- Jan Philipp Kreysing@jpkreysingJan Philipp KreysingRT @imprs_cbp: Looking for a #PhDposition in the #LifeSciences? #Apply to our #gradschool on cellular #biophysics! Prepare your documents & contact your referees. We look foward to get to know you👉 #imprs #phd @goetheuni @uni_mainz @fias_science @MPIbp @maxplanckpress0403.6K
- Jan Philipp Kreysing@jpkreysingJan Philipp KreysingRT @Beck_Laboratory: How can genetic perturbation of a central scaffolding component of the #nuclearpore result in a tissue specific defect? Work by @Reiya_Tan1guch1 and others in collaboration with @DoyeValerie makes this more conceivable (@MPIbp @IJMonod):020012K
- Jan Philipp Kreysing@jpkreysingGreat to see this method out as a preprint now. It has been an invaluable tool for me over the last months.Sergio Cruz-León @SergioCruzLeon1🧵[1/6] We achieve high-confidence localization of a wide range of macromolecular complexes, their subunits, and functional substates through 3D template matching (TM) for #CryoET. This allows us to capture vaults transporting ribosomal cargo in situ!🤯004253
- Jan Philipp Kreysing@jpkreysingJan Philipp KreysingRT @mimi1inh: Excited to share our in situ #CryoET story on the effect of a top antimalarial drug candidate on the translational landscape in #CryoFIB-milled malaria parasites! So proud of this massive team effort with @leonie_anton @_wenjing_cheng_ @mehsehret @davwcbb🥰#officially #teamtomobioRxiv @biorxivpreprintIn situ cryoET reveals inhibitor-induced perturbations in Pf80S GTPase interactions #bioRxiv058080.1K
- Jan Philipp Kreysing@jpkreysingJan Philipp KreysingRT @SergioCruzLeon1: 🧵[1/6] We achieve high-confidence localization of a wide range of macromolecular complexes, their subunits, and functional substates through 3D template matching (TM) for #CryoET. This allows us to capture vaults transporting ribosomal cargo in situ!🤯051037.4K
- Jan Philipp Kreysing@jpkreysingJan Philipp KreysingRT @biorxivpreprint: Thinner is not always better: Optimising cryo lamellae for subtomogram averaging #bioRxiv010030.8K
- Jan Philipp Kreysing@jpkreysingJan Philipp KreysingRT @MPIbp: Scientists from our @Beck_Laboratory have visualized the structural dynamics of ribosomes in human cells for the first time. Using #cryoET, they generated 3D images of ribosomes in action & deciphered the target site & mode of action of a leukemia drug 👉01405.7K
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