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Alan Yu🇭🇰
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Alan Yu🇭🇰

@AlanYuNeph

Nephrologist, physician-scientist. Director, Division of Nephrology, Jared Grantham Kidney Institute, University of Kansas @KUNeph Opinions are my own

945 Following2K Followers2.1K Posts
  1. Alan Yu🇭🇰@AlanYuNeph
    Alan Yu🇭🇰
    RT @asnpublications: New in #ASNJASN and simultaneously published with #KidneyWk: Study found empagliflozin 25 mg once daily for 12 months was safe & well-tolerated in adults with ADPKD at high risk for rapid progression. Those treated with empagliflozin had greater increase in kidney volume
    01304
  4. Alan Yu🇭🇰@AlanYuNeph
    Alan Yu🇭🇰
    RT @asnpublications: Basic Research published in #ASNJASN identified a protein called ARL13B that helps drive cyst growth in polycystic kidney disease. In mice, blocking this protein reduced cyst growth and improved kidney health, suggesting it could be a possible target for future treatments.
    0506
  5. Alan Yu🇭🇰@AlanYuNeph
    Alan Yu🇭🇰
    RT @asnpublications: New research published in #ASNJASN helps explain why people with chronic kidney disease are more prone to blood clots and points to a potential new target for preventing these serious complications.
    0407
  7. Alan Yu🇭🇰@AlanYuNeph
    Alan Yu🇭🇰
    RT @kidney_boy: Huge disappointment. High hopes...dashed
    Gregg Fonarow MD @gcfmd
    Following a recommendation from the DMD Boehringer Ingelheim has decided to discontinue the EASi-KIDNEY trial (NCT06531824) Testing vicadrostat (BI 690517), in combination with empagliflozin vs empagliflozin alone, could slow CKD and ⬇️ CV events
    0606
  8. Gregg Fonarow MD@gcfmd
    Following a recommendation from the DMD Boehringer Ingelheim has decided to discontinue the EASi-KIDNEY trial (NCT06531824) Testing vicadrostat (BI 690517), in combination with empagliflozin vs empagliflozin alone, could slow CKD and ⬇️ CV events
    0143334.1K
  9. Alan Yu🇭🇰@AlanYuNeph
    Alan Yu🇭🇰
    RT @asnpublications: Some people with HIV who carry high-risk APOL1 genes may be less likely to develop kidney disease if they also have the APOL1 p.N264K genetic variant. This finding in #ASNJASN may help doctors better understand an individual's kidney disease risk in the future.
    0206
  10. Alan Yu🇭🇰@AlanYuNeph
    Alan Yu🇭🇰
    RT @ISNkidneycare: 🏆 Lillian Jean Kaplan Prize for PKD: Feng Qian. Learn more: “I am deeply honored and humbled to receive the Lillian Jean Kaplan International Prize. This recognition reflects the collective efforts of many outstanding colleagues, trainees, collaborators, and patients whose contributions have advanced our understanding of polycystic kidney disease. While significant progress has been made, important challenges remain. I look forward to continuing the pursuit of discoveries that deepen our understanding of PKD and ultimately improve the lives of patients and families affected by this disease.” Prof. Qian
    0305
  11. Alan Yu🇭🇰@AlanYuNeph
    Alan Yu🇭🇰
    RT @asnpublications: Measuring slit diaphragm autoantibodies could transform care by distinguishing low-risk from high-risk autoimmune podocytopathies, improving prognosis, treatment selection, and transplant planning, according to new study in #ASNJASN.
    01706
  13. Alan Yu🇭🇰@AlanYuNeph
    Alan Yu🇭🇰
    RT @asnpublications: APOL1 risk variants (G1/G2) form membrane pores that increase Ca²⁺ influx and kidney cell damage. The APOL1 inhibitor VX-147 and the M1 (N264K) variant reduced Ca²⁺ entry and improved cell survival, highlighting potential therapies for APOL1 kidney disease. #ASNJASN
    01005
  14. Alan Yu🇭🇰@AlanYuNeph
    Alan Yu🇭🇰
    RT @asnpublications: #BasicResearch study in #ASNJASN shows that blocking gut microbial TMAO production reversed key features of established CKD in mice, further implicating the gut-kidney axis as a promising therapeutic target.
    0506
  15. Alan Yu🇭🇰@AlanYuNeph
    Alan Yu🇭🇰
    RT @PRomagnani: Our new study in @JASN_News: Autoantibody specificity matters: anti-nephrin, anti-podocin, and anti-KIRREL1 antibodies define autoimmune podocytopathies with distinct phenotypes, prognosis, and transplant recurrence risk.
    03007
  16. Alan Yu🇭🇰@AlanYuNeph
    Alan Yu🇭🇰
    RT @DrDanMO: @polymath1959 But @kidney_boy does! It’s all about a low urine output for a bit!
    Joel M. Topf, MD FACP @kidney_boy
    @bryanacotton1 DOn't be fooled by this dreck. The real story is in E Table 3 The dapa acted as a diuretic to prevent KDIGO defined AKI where oliguria can trip the definition. When looking at creatinine defined AKI, a BIG NS for the study
    0104
  17. Joel M. Topf, MD FACP✓@kidney_boy
    Posts @bryanacotton1
    @bryanacotton1 DOn't be fooled by this dreck. The real story is in E Table 3 The dapa acted as a diuretic to prevent KDIGO defined AKI where oliguria can trip the definition. When looking at creatinine defined AKI, a BIG NS for the study
    Download
    16313.9K
  18. Alan Yu🇭🇰@AlanYuNeph
    Alan Yu🇭🇰
    RT @asnpublications: New ADPKD #basicresearch identifies the PTH–Pth1r–primary cilia pathway as a driver of kidney cyst growth. Blocking Pth1r reduced cyst progression in mouse models, while cinacalcet lowered PTH levels and cyst burden, highlighting a promising new therapeutic target. #ASNJASN
    01405
  19. Alan Yu🇭🇰@AlanYuNeph
    Alan Yu🇭🇰
    RT @asnpublications: Welcome to our newest Editorial Fellows and Junior Associate Editors! ASN Publications is excited to welcome this talented cohort of early-career scientists as they begin editorial training and help shape the future of nephrology scholarship.
    0705
  20. Alan Yu🇭🇰@AlanYuNeph
    Alan Yu🇭🇰
    RT @PKDFoundation: Congratulations, Dr. Feng Qian, professor of medicine at the University of Maryland School of Medicine in Baltimore, Maryland, on receiving the 2027 Lillian Jean Kaplan International Prize for Advancement in the Understanding of polycystic kidney disease!
    01208
  21. Alan Yu🇭🇰@AlanYuNeph
    Alan Yu🇭🇰
    RT @PKDFoundation: The PKD Foundation is deeply saddened by the passing of Dr. James Calvet, a pioneering researcher whose work helped shape our understanding of PKD and inspired generations of scientists.
    03010
  22. Alan Yu🇭🇰@AlanYuNeph
    Alan Yu🇭🇰
    RT @Boletta_Lab: This is truly sad news. I have dear memories of Jim when I was starting my lab and I felt him as a kind, thoughtful supporter. He inspired many to pay it forward. R.I.P 🙏
    PKD Foundation @PKDFoundation
    The PKD Foundation is deeply saddened by the passing of Dr. James Calvet, a pioneering researcher whose work helped shape our understanding of PKD and inspired generations of scientists.
    0109
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