EJPC Editor-in-Chief

✅Lp(a) at the #AHA congress: no 💊 pharma yet on the HORIZON. So should we still screen it ? Does Knowing Lp(a) Change What We Do? See the debate in #EJPC ⤵️

Acute exposure to 🚬 promotes vascular dysfunction, ⬆️ venous CO2, and acute 🧬 damages in healthy 🧑‍🦱👩‍🦱 adults. Explore more insights in the recent #EJPC paper ⤵️ 🔗

Are visits to 🌳 🏞️ areas associated with ⬇️ risk of #MACE in the metropolitan areas? Explore the association in the recently published paper in the #EJPC ⤵️ 🔗

💊 Lower inflammation, but no improvement in arterial stiffness. In the COHERENT trial, 6 months of colchicine significantly reduced hsCRP but did not improve arterial stiffness in patients with treated hypertension. 🔗

Is apoB alone enough to capture lipoprotein-related coronary risk? In>40,000 participants across ethnic groups, risk-weighted apoB(incorporating triglycerides and Lp(a)) captured additional coronary risk, with modest improvements in risk discrimination. 🔗

🫀 From plaque formation to carotid stenosis: does lipoprotein(a) play a role? Elevated Lp(a) (≥50 mg/dL) to both plaque development and progression to significant carotid stenosis, highlighting its relevance across the atherosclerotic continuum. 🔗

In patients with coronary heart disease, 150 min/wk of moderate-intensity physical activity was associated with 38% lower all-cause mortality. A dose–response meta-analysis of 176,862 patients highlights the benefits of low-to-moderate activity levels. 🔗

📉 Fewer ischemic events, but more bleeding after heart attack? SWEDEHEART data showed declining CV events but increasing bleeding complications, particularly upper GIS bleeding. Tailored antithrombotic therapy and gastroprotection remain essential. 🔗

🫀Fear of cardiac symptoms may become a barrier to recovery. A systematic review of 26 studies (n=9,628) found heart-focused anxiety in 15–49% of patients with CVD, linked to exercise avoidance and poorer outcomes. 🔗

🤰🫀 Hyperlipidaemia in pregnancy: physiology or cardiovascular risk? A timely review of peripartum lipid changes, maternal & fetal outcomes, treatment options, and key evidence gaps. 🔗

Can targeting the gut microbiome improve cardiometabolic health early in life? 📊 Microbiome-targeted interventions reduced BMI z-score and CRP, with no significant changes in lipids, insulin resistance or blood pressure. 🔗

♀️ Do reproductive factors shape cardiovascular risk after menopause? This study found that later menopause was associated with a lower risk of cardiovascular events, while evidence for other reproductive factors remains limited or uncertain. 🔗

This systematic review and meta-analysis suggests that LDL-C-lowering therapies may offer a greater benefit in preventing first-time MI compared with recurrent MI 📖 @escardio @AboyansV @SilCastelletti @PeroneFrancesco @PTBuketAkinci @SMosteoru @TimKambic

In this population-based cohort, standard modifiable CV risk factors status significantly impacted long-term but not short-term mortality following MI 📖 @escardio @AboyansV @SilCastelletti @PeroneFrancesco @PTBuketAkinci @SMosteoru @TimKambic

Younger age at first diagnosis is strongly associated with lower risk of subsequent events in patients with cerebrovascular disease (stroke) and in women with peripheral artery disease or abdominal aortic aneurysm 📖 @escardio @AboyansV @SilCastelletti

In a study of urban areas in California, the rate of heart attacks is predicted to be ⬆️ in census tracts with higher urban heat island intensity 📖 @escardio @AboyansV @SilCastelletti @PeroneFrancesco @PTBuketAkinci @SMosteoru @TimKambic

Exposure to PM2.5 is modestly associated with the presence of CAC, particularly when combining residential and workplace exposures 📖 @escardio @AboyansV @SilCastelletti @PeroneFrancesco @PTBuketAkinci @SMosteoru @TimKambic

In this study, a total of 856 357 incident acute CVD cases were used from CVD surveillance in China in 2023. ✅ Higher temperatures ⬆️ the risk of acute CVD, with extreme heat exposure leading to a 17% higher risk 📖 @escardio @AboyansV @SilCastelletti

In this study, PM2.5 constituents and greenness were estimated around the residence of 411 364 UK adults. Long-term exposure to PM2.5 constituents was positively associated with the incidence of AF, whereas greenness was inversely associated with it 📖

This study of 464 541 UK Biobank participants found that lifetime exposure to fine particulate matter pollution (PM2.5) and their chemical components ⬆️ the risk of developing atrial fibrillation and progressing to heart failure 📖 @escardio @AboyansV