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Matthias Lutolf
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Matthias Lutolf

@TheLutolfLab

Institute of Human Biology (IHB), Roche, Basel, Switzerland. Institute of Bioengineering, EPFL, Switzerland. #organoids, #tumoroids, #stemcells, #bioengineering

357 Following6K Followers213 Posts
  1. Matthias Lutolf@TheLutolfLab
    Bioengineered GI organoids just got an upgrade! Our new Transgel system combines 3D complexity with bilateral accessibility & remarkable observability, enabling advanced studies on tissue dynamics, stem cell niches, and host-pathogen interactions.🔬 👉
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  2. Matthias Lutolf@TheLutolfLab
    Posts @TheLutolfLab
    From gastric to colonic tissues: Transgel organoids replicate GI tissue architecture, including stem cell patterning and improved differentiation over time! There seem to be conserved mechanisms for geometry-induced stem cell organization and differentiation across the GI tract.
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  3. Matthias Lutolf@TheLutolfLab
    Posts @TheLutolfLab
    Transgels enable live imaging of parasite infection in caecal models. Watch larvae invade epithelia in real-time & observe mechanisms like syncytial tunnel formation. Huge congrats to super talented @MoritzHofer_ and thanks to Maria Duque-Correa for the fantastic collaboration!
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  4. Matthias Lutolf@TheLutolfLab
    Join us @Roche's Institute of Human Biology (IHB) as a Scientific Group Leader! Lead innovative research in #HumanModelSystems such as #Organoids. We especially seek applications aligned to our commitment to diversity and inclusion.  More  #TeamIHB #pRED
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  5. Matthias Lutolf@TheLutolfLab
    Please join us in shaping the future of human biology research and help to translate it into real-world applications in pharmaceutical research and development!
    Institute of Human Biology @IHB_Research
    📢Open call for Scientific Group Leads! #TeamIHB seeks stellar Junior & Senior scientists to start research groups on innovative and translational #HumanModelSystems. Expertise in #Immunology, #Neurology, #Ophthalmology, #Metabolism or #Oncology a➕! More
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  7. Matthias Lutolf@TheLutolfLab
    Fantastic paper that exemplifies the credo and mission of @IHB_Research: bold and creative young scientists as hands-on leads + projects combining biology, engineering, computation and drug development + extremely close collaboration between multiple research groups! Congrats!!
    Gray Camp @GrayCampLab
    Exciting new inroads into human biology and therapy development: Human intestinal organoids with an autologous tissue-resident immune compartment! #Gjorevski #Cabon #IHB @Nature @IHB_Research
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  9. Matthias Lutolf@TheLutolfLab
    Following our recent breakthrough on mouse mini-intestines for ex vivo tumor development, we asked ourselves: can this technology be applied to cells from cancer patients? We are excited to announce the answer to this question in our latest publication:
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  10. Matthias Lutolf@TheLutolfLab
    Posts @TheLutolfLab
    and the identification of immunomodulatory interactions among different components of the tumor microenvironment.
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    11131.9K
  12. Matthias Lutolf@TheLutolfLab
    Imagine growing a miniature version of the human intestine in the lab to study gut biology in great detail and test medicines before clinical trials? We are happy to share our latest publication on bioengineered human mini-intestines: Let’s dive in!
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  13. Matthias Lutolf@TheLutolfLab
    Posts @TheLutolfLab
    These bioengineered mini-intestines are a powerful tool for exploratory and translational research. They enable advanced modeling of the intestinal #epithelial barrier for drug testing and capturing the multicellular complexity of gastrointestinal diseases.
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    11132.2K
  15. Matthias Lutolf@TheLutolfLab
    Thanks, this was a lot of fun!!
    Petrova Lab – Vascular and Tumor Biology @PetrovaLab
    🤩The first Swiss Gut Workshop was a success! So exciting to dive into the latest gut research from organoids to the gut-brain axis, all set against the stunning Lavaux landscape🤩 🙏 to all participants for sharing amazing science and @UNIL for support!
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  16. Petrova Lab – Vascular and Tumor Biology@PetrovaLab
    🤩The first Swiss Gut Workshop was a success! So exciting to dive into the latest gut research from organoids to the gut-brain axis, all set against the stunning Lavaux landscape🤩 🙏 to all participants for sharing amazing science and @UNIL for support!
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    22346K
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