Tristan Roberts

Saint Shannon @shannon_sense

There's a lot of gay ppl doing culture commentary now who do not know cultural references beyond the ones that have been memes on the internet. In previous generations being gay in that space was all about being a nerd about cultural minutiae of the past. That was the foundation

Sofia Coppium @indianloonie

Going to the barber asking for the James Somerton

Austin Chen @akrolsmir

yeah I recall hearing a bit about someone getting kicked out of LO for sleeping over, maybe it was WBE. obviously if he's banned we won't have him at Manifest maybe this reflects badly on me, but I've actually read a lot of this person's substack, and found it, idk, at least quite captivating. (while not endorsing a lot of his behavior). I find his writing better written than ~half of inkhaven I also have a lot of sympathy for someone who just really doesn't have any money (he says, $800 net worth); but still wants to meet and talk to other interesting smart people. Manifest has historically provided many complimentary tickets to eg students for this reason seems like the kind of thing jesus would do?

Karl Pfleger @KarlPfleger

Crazy, unexpected science news today: the brain is actually 2 colocated but independent organs that develop from 2 totally separate progenitor cells in early development. Big implications for some research areas (eg ALS) & for creating ethical brainless clones for transplant.

Mike Hart, M.D @drmikehart

The FDA just approved a myostatin inhibitor for a rare muscle wasting disease to prevent muscle loss. Guaranteed this will be approved soon to be taken with GLP-1s. Myostatin inhibitors will be as big as GLP-1s.

More Perfect Union @MorePerfectUS

Anthropic Is building a surveillance system to monitor activists using a “pre-crime” approach that tries to predict incidents before they happen. The extensive monitoring system that the AI company is building is aimed primarily at keeping tabs on activists who oppose the rapid development of artificial intelligence. More from @DRBoguslaw below:

Michael Levin @drmichaellevin

Here it is - the official, revised, peer-reviewed version of my Platonic Space paper. Of all the many unpopular positions I’ve taken over the decades - bitter controversies around the origin of left-right asymmetry in embryogenesis, bioelectricity and genetics, diverse intelligence, etc., this one has by far generated the most pushback: serious (grateful for those!) and energetic attempts to move me to other views, pleas to just drop it and not talk about it (for several different reasons), nasty emails and accusations, impacts on reviews of papers that have nothing to do with this, etc. Kind of amazing to me how incendiary this is. What can I say... Our job is to call it as we see it, and right now for me, this is it. Apologies to collaborators and colleagues for any shrapnel! Time will tell if this pans out or not; I've placed my bets. And btw, if you think this stuff is weird and uncomfortable, just wait… There’s much more on the way. The knob turns slowly but as long as the data keep coming, I'm going to say what I think it all means and follow it to the next steps it enables. Buckle up!