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As voters head to the polls on 3 November for the US mid-term elections, a political shake-up could be coming to Washington DC — with substantial consequences for the country’s scientific landscape.

Nature research paper: Zeolite-catalysed olefin carbonylation based on tuning spatial confinement

Nature research paper: A single-molecule spin–photon interface

The Intergovernmental Panel on Climate Change faces perhaps the most serious crisis in its nearly 40-year history — but it is too precious to lose

Single-cell profiling of nearly 2,000 people brings scientists closer to understanding the link between genetic variation, gene expression and health

Book review 📚 Can scientists reliably tell if a novel is written using AI?

Scientists have ruled out yet another source of the Universe’s elusive dark matter: ‘stupendously’ large black holes

How can we best capture clinically important aspects of a person's immune health?

Nature research paper: Presynaptic homeostasis mediated by exocytosis of a SNARE protein

Latest from the Nature Careers Podcast 🔊 Mentoring a lab colleague? Share your ‘CV of failures’ with them

To ensure that ideas translate into improvements in mental-health care, they must be pursued with rigour and in a way that ensures they have the widest possible reach

These scientists explain how they stop their essential lab kit from going missing

A jury weighs in on whether teaching assessments are popularity contests or an important tool Read the full story, and cast your vote:

Nature research paper: Cold activates a BH2 metabolic network promoting longevity and proteostasis

Nature research paper: Spatial and sectoral water demand assessment for the African continent

Researchers are optimistic about psychedelic drugs as potential treatments for depression and mood disorders, despite pushback having stalled the field

Single-cell profiling of nearly 2,000 people brings scientists closer to understanding the link between genetic variation, gene expression and health

Nature research paper: WEE1 opposes APC/CCDH1 activity to promote S phase entry

Latest from the Nature Podcast 🔊 This Arabian desert was once a lush paradise. Why did ancient humans avoid it?

A 3D-printing method has made single crystals of metals and alloys in complex shapes and up to one metre in length, as needed for advanced technological applications

Nature research paper: Alzheimer’s disease genetics converges on microglial and neuronal dysregulation

Nature research paper: A single archaeon couples long-chain fatty acid oxidation to methanogenesis

A project to improve understanding of an often-neglected group in academia aims to help its members to navigate career uncertainty

Brazil’s President Lula won his bid for re-election on 25 October, to the relief of many scientists who feared for the future of Brazilian research if his opponent prevailed.

Nature research paper: Genetic variants shape single-cell chromatin accessibility and disease risk

As the pursuit of increasing human longevity and healthspan has grown, researchers and companies are investigating anti-ageing measures for dogs and cats, from probiotic kibble to gene therapy to treat canine heart disease.

Nature research paper: Pharmacological inhibition of METTL1 as a therapy against solid and blood cancers

Amphibians were able to live in the sea 237 million years ago, according to new research

Nature research paper: SWI/SNF complexes shape 3D chromatin architecture through CTCF and cohesin

Nature research paper: An environmentally regulated dichotomy in cell lineages of the root

Around the time of birth, the developing human brain mysteriously tidies up by purging itself of a vast number of mutation-riddled neurons

Book review 📚 Women might have invented language — but not alone

It’s unclear whether Elon Musk meant for his suggestion of a giant sunshade in space to be taken seriously

Nature research paper: CD51 delineates functionally distinct astrocyte subtypes in neural circuits

As poor publishing practices proliferate, scholarly databases are under pressure to ensure the titles they list are reputable

Our survey of nearly 4000 researchers shows that if you're struggling to make ends meet, you're not alone

This rise is attributable, in part, to the ease of writing applications with artificial-intelligence tools

Could a blood sample, a brain scan and a look at your phone data transform how your psychiatrist treats you?

50 years after the publication of The Selfish Gene, it's time for books that capture the complexity of life to take centre stage

Nature research paper: The contribution of salt marshes to wave attenuation during extreme storms

Trust in science and researchers has fallen following the COVID-19 pandemic Read the full story:

Nature research paper: Persistent neuronal stress signalling underlies Angelman syndrome phenotypes