Casey Handmer✓

Casey Handmer @CJHandmer

You can now enjoy a colored relief map render of this dataset streamed through Google Earth. Download the .kml file ( and open it in your Google Earth Pro client. Enjoy!

unusual_whales @unusual_whales

Only 2.2% of mortgaged homes are underwater, per Goldman Sachs. In 2008, it was roughly 1 in 4.

Casey Handmer @CJHandmer

We need to start measuring publicly funded California infrastructure grifts in units of kiloPorsches, where one kiloPorsche is equivalent to enough waste that the contracting body (typically some government agency) could have instead purchased 1000 Porsches, and instead the contractor and/or their consultants, if they ran the grift efficiently, could purchase 1000 Porsches with public money. This project is 30 kiloPorsches. California's state budget is between 300 and 1500 kiloPorsches. It's a big club and you're not in it.

Oren Ben-Joseph @orenbj

Wow... LAX People Mover flashover was caught on video

David Galbraith @daveg

It's quite strange that the house of cards is only now falling on a $5 trillion dollar company that in the 15 years since Jobs passed away and when it was worth 15 times less, has released a pair of peripherals to the iPhone, the airpods and watch, has no best of breed apps from email to maps, had to abandon the only genuinely new product, the Vision Pro and has the worst AI offering of its competitors, in Siri.

Ashlee Vance @ashleevance

Feels like I've spent my career covering the things Neal Stephenson predicted. So was a true pleasure to have a nice, long chat with him. We did swords for @CJHandmer and others. I prodded him on Blue Origin, Bezos and our AI overlords. Lots more.

Casey Handmer @CJHandmer

A delete function for the immune system would be incredibly valuable.

Bowen Jing @bjing2016

Today, in collaboration with Anthropic, we’re excited to share rapid initial progress towards an antibody treatment for food allergy, which affects over 200 million people worldwide, discovered with the help of Claude. At Divergence Labs, we believe that AI can unlock the next generation of antibody therapeutics with more effective mechanisms than before. Such mechanisms are urgently needed in food allergy, which involve overcoming one of the tightest affinity protein pairs in immunology, IgE and its receptor FcεRI, on mast cells. Treatment with Xolair—the only approved antibody for food allergy—sequesters circulating IgE, but mast cells remain sensitized for weeks to months due to the extraordinarily slow dissociation of IgE from FcεRI. We envision a treatment that actively pulls IgE off of FcεRI, without waiting for natural dissociation. Like picking a lock, this requires the right combination of geometry and force. Our research team, working with Claude, ideated on mechanisms to accomplish this disruption, and converged on an antibody format with two arms with different functions and epitopes. Within one month, we designed, synthesized, and experimentally confirmed the biophysical function of the two arms, which we are now assembling into full therapeutic formats.

Aeriq @Bhavyathinks

One of the most underrated Harry Potter moments was left out of the theatrical cut of Harry Potter and the Deathly Hallows.

Blake Scholl 🛫 @bscholl

Dear founders and VCs calling your thing “foundry” or “forge:” Please choose another name unless your thing is an actual foundry or forge. Sincerely, American Actual Reindustrialization

David C 🚀🛰️📡 @kanstin

@CJHandmer @TerraformIndies @buildmattw Only 60k in costs due to error for a project of that size is pretty incredible imo

Andrew Curran @AndrewCurran_

Claude is the only author listed on this paper, in contrast to the OpenAI papers, where the human co-authors are listed. There are a lot of strange things about this. It's fun to guess. Conjecture time. I shall reveal my thought traces: Claude Fable 5.1 and Claude Mythos 5.1 are the same model with the same weights; the only difference is the guardrails. We are about to get Fable 5.5 - in fact, Fable 5.5 is ready to deploy now, and Anthropic could do so at any time. If they follow the same pattern, and I think they will, this implies the existence of a Mythos 5.5. I believe Mythos 5.5 wrote this paper. The way this is worded - 'Provenance. The core algorithm was found on October 16 by an internal Claude research model with 14M output tokens and no human input. Anthropic researchers worked with Claude to improve the presentation, resulting in this paper. Independently and concurrently, an internal model at OpenAI claims to have proven a similar result [Ope26]' - makes me think Claude was not prompted to solve this. I think Mythos was asked to autonomously find and choose general open problems to solve itself, as part of an unannounced project to demonstrate recent advances in autonomy and research taste. You can see this taste in Fable 5.5's student; Opus 5.5. This recent advancement in taste and creativity - which happened in September - is not clearly expressed in benchmarks, but it is why so many people are currently switching to Claude as their primary. I think this research project will be announced with Fable 5.5, as part of Anthropic's big media blitz to boost the IPO. One of the things X has taught me is that many people, if they can't see something moving, can't imagine it moving. This causes them to be continuously surprised by developments in this industry, because the frontier is invisible. I think this project has been running autonomously for some time and has made an unknown, and probably significant, number of discoveries, and not only in math. Do not think Anthropic has been sitting idly while OpenAI repeatedly makes these huge science announcements. This is a war. This ETH result was released without any announcement from Anth at all despite its significance, and they only did so to respond to OpenAI's ETH reveal. They posted it late last night without saying anything. It was up for hours before levent even mentioned it. What value has one coin to a dragon who sleeps upon a mountain of them? This makes me think they are sitting on a pile of discoveries, a golden hoard, and they are saving them up for the big IPO shock-and-awe campaign which will soon begin. And when it does, they will announce multiple discoveries across many fields.

Colin McCarthy @US_Stormwatch

Category 5 (beyond extreme) marine heatwave conditions are being observed offshore San Diego, where water temperatures are up to 77°F. California's severe marine heatwave is also marching north and has now reached Northern California, with water up to 68°F offshore Santa Cruz.

Rob Petrozzo @robpetrozzo

Sotheby’s just sold Jodi, a Nanotyrannus (a smallish friend of T-Rex) for: *$47,000,000* High estimate was $9M. 2nd most expensive dinosaur EVER. I really think it’s because A) low estimate was very inviting B) it’s the perfect size at ~20ft This is going in a home, imo

The Kobeissi Letter @KobeissiLetter

BREAKING: Microsoft, $MSFT, is offering buyouts to 60,000 workers as part of the company’s efforts to cut costs amid AI adoption, per Bloomberg. Personnel on select teams in the US, Canada, India, and the UK at a vice president level and below will be eligible. This reflects ~27% of Microsoft's total workforce.

MTS @MTSlive

SITUATION DETECTED: An Anthropic internal model also produced an independent refutation of the Exponential Time Hypothesis, it was discovered on October 16.

Marcus @Owenby

we did a thing