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KenOliveLab
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KenOliveLab

@KenOliveLab

Asc Prof. of Medicine, Columbia University, views own. Pancreatic cancer, translational therapeutics, metabolism, systems, paracrine interactions. It all fits.

369 Following3.7K Followers2.5K Posts
  1. KenOliveLab@KenOliveLab
    OK, this one is really meaningful for our whole team. Our preclinical paper on pan-RAS inhibition in pancreatic cancer is now online @Nature. Led by OliveLab student @ulawasko and Revolution Medicines colleagues JingJing Jiang and Mallika Singh.
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  2. KenOliveLab@KenOliveLab
    Sad to miss the first #PCAMChat24. Briefly, this is Ken Olive from @columbiacancer. I lead a translational research lab dedicated to #PDAC research. Excited to join in for part 2!
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  3. KenOliveLab@KenOliveLab
    Suddenly seeing a huge number of fellow scientists show up on BlueSky. FYI I'm one of them. Come follow me: @kenolivelab.bsky.social
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  5. KenOliveLab@KenOliveLab
    New post on our website with updated information on the clinical development of RAS inhibitors for pancreatic cancer. I'll summarize on twitter sooner, but here's the full version:
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  7. KenOliveLab@KenOliveLab
    Really excited for my postdoc @MC_Hasselluhn who received a 4th percentile score on her K99 application. Folks, she's on the job market!
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  8. KenOliveLab@KenOliveLab
    KenOliveLab
    RT @Aiims1742: Revolution Medicines has launched its ph 3 study of RMC-6236 (RASolute 302) in patients with previously treated #PancreaticCancer. 1:1 randomization against physician’s choice of chemotherapy. A registration trial for KRAS inhibitor in pancreatic cancer!
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  9. KenOliveLab@KenOliveLab
    KenOliveLab
    RT @simonduerr: There is a new tool on BioIcons to turn any protein (in PDB format) into a 2D vector illustration in SVG format. You can upload any PDB file or import from PDB, AlphaFoldDB or ESMFoldDB. Feedback welcome :)
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  10. KenOliveLab@KenOliveLab
    KenOliveLab
    RT @columbiacancer: We are thrilled to welcome Michel Sadelain, MD, PhD, a global pioneer in CAR-T therapies, to Columbia and the HICCC.
    Columbia Medicine @ColumbiaMed
    Columbia welcomes CAR-T pioneer Michel Sadelain, MD, PhD, as the inaugural director of the new Columbia Initiative for Cell Engineering and Therapy and director of the Cancer Cell Therapy Initiative at the Herbert Irving Comprehensive Cancer Center. ➡️
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  11. Columbia Medicine✓@ColumbiaMed
    Columbia welcomes CAR-T pioneer Michel Sadelain, MD, PhD, as the inaugural director of the new Columbia Initiative for Cell Engineering and Therapy and director of the Cancer Cell Therapy Initiative at the Herbert Irving Comprehensive Cancer Center. ➡️
    Download
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  12. KenOliveLab@KenOliveLab
    KenOliveLab
    RT @ARNesLab: I am excited to see this story by my talented Master's Student, Kristina Høj. Her research dives into age-related decline in pancreas regeneration and how it’s linked to a proinflammatory response to injury. @AGA_GHAdvances,@UCPH_BRIC,
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  13. KenOliveLab@KenOliveLab
    KenOliveLab
    RT @Aiims1742: New online perspective article @CR_AACR article timed with the ongoing #PancreaticCancer stroma session at #AACRPan24 Pancreatic Cancer-Associated Fibroblasts: Where do we go from here? A conversation with three experts on the PDAC stroma (@MaraShermanLab @ednacukierman & @Pasca_Lab) led by three fantastic early career faculty (@MC_Hasselluhn @DebVendramini & Eileen Carpenter @UMICHpancreas). Lots of great perspectives on this complex subject!
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  14. KenOliveLab@KenOliveLab
    Hiring committees take note...
    Alvaro Curiel-García, PhD @AlvaroCurielGa1
    That feeling when you submit your first application for a tenure-track faculty! 🧑‍🔬 I am planing to create a "Translational systems oncology" laboratory focused on cell states, hypoxia and targeted therapies where I will use both wet and dry approaches. #faculty #academiclife
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  15. Alvaro Curiel-García, PhD@AlvaroCurielGa1
    That feeling when you submit your first application for a tenure-track faculty! 🧑‍🔬 I am planing to create a "Translational systems oncology" laboratory focused on cell states, hypoxia and targeted therapies where I will use both wet and dry approaches. #faculty #academiclife
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  16. KenOliveLab@KenOliveLab
    KenOliveLab
    RT @cudldrc: Congratulations to CU-DLDRC Associate Director, Timothy Wang, MD, who is the new Vice Chair for Academic Programs for the Department of Medicine at the Vagelos College of Physicians and Surgeons! Dr Wang will add this new role to his portfolio effective September 3rd, 2024.
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  17. KenOliveLab@KenOliveLab
    KenOliveLab
    RT @zeribechike: @NwosuLab @CornellMBG has opened a call for postdoc applicants. Please kindly repost and or forward to potential applicants. Job posting: Lab website:
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  19. KenOliveLab@KenOliveLab
    When everything is urgent, nothing is urgent.
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  20. KenOliveLab@KenOliveLab
    The Olive Lab is looking for a postdoc to lead our translational program on RAS inhibition in pancreatic cancer. Should have exceptional scientific and project management skills, and experience with transdisciplinary research. Must be a good human.
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  21. KenOliveLab@KenOliveLab
    Posts @KenOliveLab
    They present a preliminary design of a planned Phase 3 trial in 2nd line PDAC patients, randomized to physician's choice.
    Download
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  22. KenOliveLab@KenOliveLab
    Posts @KenOliveLab
    Data available on their website at:
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  23. KenOliveLab@KenOliveLab
    Posts @KenOliveLab
    Really exciting times for the PDAC field, offering real hope for patients. This is just monotherapy. Can't wait to see combinations!
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  24. KenOliveLab@KenOliveLab
    Stunning interim clinical trial data from Revolution Medicines... PFS = 8.1 mo in 2nd line KRAS G12-mutant metastatic #PDAC. OS not yet reached, but already more than a year! Benchmark PFS for this group is 2-3.5 months, behnchmark OS is 6.1-6.9. 1/
    Download
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  25. KenOliveLab@KenOliveLab
    Posts @KenOliveLab
    All standard caveats apply: single arm data, non randomized, highly scrutinized patients, early phase, selected group, etc. Even with the caveats, the results are exciting IMHO.
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