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🇺🇦Peter Caravan🇺🇦
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🇺🇦Peter Caravan🇺🇦

@PeterCaravan

immigrant, scientist, enophile, husband, dad, professor, molecular imaging at Massachusetts General Hospital and Harvard Medical School

572 Following1.3K Followers1.5K Posts
  1. 🇺🇦Peter Caravan🇺🇦@PeterCaravan
    Great opportunities opening up here!
    Gordon Center for Medical Imaging @MGHGordon
    The Gordon center started the new year with a new biological emphasis under new leadership: @MatthiasNahrend is our new director. Umar Mahmood will lead a technology-focussed sibling, the Center for Nuclear Medicine & Theranostic Sciences.
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  2. Gordon Center for Medical Imaging@MGHGordon
    The Gordon center started the new year with a new biological emphasis under new leadership: @MatthiasNahrend is our new director. Umar Mahmood will lead a technology-focussed sibling, the Center for Nuclear Medicine & Theranostic Sciences.
    Download
    513015.1K
  8. 🇺🇦Peter Caravan🇺🇦@PeterCaravan
    This paper from @Mariane_LeFur had 3 provocative findings. 1. Gadolinium retained in kidneys is invisible to T1w MRI until it is present at high 100s of micromolar. Gd is retained in kidneys at several orders of magnitude more than in brain. #Kidney 1/6
    Radiology @radiology_rsna
    Following administration of four different gadolinium contrast agents to healthy rats, mass spectrometry showed the highest concentration in the kidney cortex at day 17. @PeterCaravan @Mariane_LeFur @MGHMartinos @MGH_RI @i3MGH
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  10. 🇺🇦Peter Caravan🇺🇦@PeterCaravan
    Posts @PeterCaravan
    3. At 7-8 weeks after dosing the gadolinium retained in the rat kidneys was intact chelate. This was true of all 4 compounds tested including the linear chelate gadobenate. 5/6
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  11. 🇺🇦Peter Caravan🇺🇦@PeterCaravan
    Posts @PeterCaravan
    Despite all that Gd, there were no histological signs of kidney damage. Would be worth testing if this is true in older rats or those with prior kidney injury. End
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  17. 🇺🇦Peter Caravan🇺🇦@PeterCaravan
    Nice work from Phil and Iris and a great collaboration with Bryan Fuchs, Bob Colvin @MGHKidneys and @pfizer colleagues to image fibrotic disease activity in the kidneys
    JASN_News @JASN_News
    In most CKDs, lysyl oxidase oxidation of collagen forms allysine side chains, which then form stable crosslinks. This study shows MRI using Gd-OA is potentially a valuable tool for detecting and staging renal fibrogenesis @PeterCaravan @i3MGH
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  18. JASN_News@JASN_News
    In most CKDs, lysyl oxidase oxidation of collagen forms allysine side chains, which then form stable crosslinks. This study shows MRI using Gd-OA is potentially a valuable tool for detecting and staging renal fibrogenesis @PeterCaravan @i3MGH
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    04185.4K
  23. WMIS WMIC@WMISWMIC
    This week's MIB Paper of the Week focuses on receptor tyrosine kinase inhibitors, their role in tumorigenesis, and using HER3 PET imaging in gastric cancer models. Great work by @ShadiEsfahani et al.! @MGHImaging
    03133.3K
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