Prof Chris P Gale@cpgale3
Clinical Lead for #MINAP , the largest continuous collection single healthcare system #heartattack registry.
00358.9K
Prof Chris P Gale
@cpgale3
Professor of Cardiovascular Medicine, Honorary Consultant Cardiologist. Specialist adult cardiovascular care: putting research into practice to benefit patients
1.7K Following13.5K Followers19.4K Posts
- Prof Chris P Gale@cpgale3Gosh…Ruslan Rust @rust_ruslanLots of debate this week on whether journals should ban AI in peer review. We actually tested this in our new preprint, and the results were pretty clear to me. For context, I've reviewed for most of the big journals and evaluated 1,000 human reviews as an editor. I love to read and evaluate science. TLDR: From now on I won't do any peer review without AI. For clinical trials, I'd even call human-only review dangerous 🧵00044
Lots of debate this week on whether journals should ban AI in peer review. We actually tested this in our new preprint, and the results were pretty clear to me. For context, I've reviewed for most of the big journals and evaluated 1,000 human reviews as an editor. I love to read and evaluate science. TLDR: From now on I won't do any peer review without AI. For clinical trials, I'd even call human-only review dangerous 🧵
2910639931.7K- Prof Chris P Gale@cpgale3Prof Chris P GaleRT @OliverVarhelyi: One month ago, Europe kicked off its very first #EUScreeningWeek. 450+ activities. All 27 🇪🇺Member States. Around 900 places to check your numbers. To every volunteer, pharmacist, doctor, nurse, student &partner who brought prevention closer to people: thank you. #KnowYourNumbers0208
- Prof Chris P Gale@cpgale3Prof Chris P GaleRT @Channel4News: Two high-speed trains have collided in Spain on the line connecting Madrid to Spain's southern Andalusia region. At least 30 people have been killed.021010
- Prof Chris P Gale@cpgale3#lorundrostat #hypertension ▶️ Mineralys reports its Explore #CKD trial (59 adults, uncontrolled BP, #CKD & #albuminuria; crossover RCT) is published. Added to ACEi/ARB & SGLT2i, it cut automated office SBP by 7.5 mmHg vs placebo (95% CI 2.7 to 12.3).
138323 - Prof Chris P Gale@cpgale3#cardiomyopathy #MedEd The 2023 ESC guideline classifies cardiomyopathy by phenotype: HCM; DCM; non dilated LV cardiomyopathy (NDLVC); ARVC; & restrictive. Each phenotype should prompt a systematic search for an underlying genetic or acquired cause. #cardiotwitter
122244 - Prof Chris P Gale@cpgale3Here’s another #stroke RCT: MILDMT @NEJM In 300 patients with mild #stroke from large vessel occlusion & substantial at risk tissue, endovascular therapy <24h gave mRS 0 to 1 at 90 days in 69.4% vs 50.0% (OR 2.32, 95% CI 1.41 to 3.81); 13.2% had serious procedural complications.
136360 - Prof Chris P Gale@cpgale3The LATEMT RCT @NEJM… In 336 patients with large vessel #stroke & salvageable tissue at 24 to 72h, endovascular therapy improved 90 day function vs standard care (common OR 1.74, 95% CI 1.19 to 2.55), but symptomatic intracranial haemorrhage was 4.8% vs 0% & death 6.0% vs 1.8%.
036342 - Prof Chris P Gale@cpgale3Prof Chris P GaleRT @Heart_BMJ: Myocardial infarction with non-obstructive coronary arteries: a pathway to achieve guideline adherence018012
- Prof Chris P Gale@cpgale3#AI @LancetDigitalH ▶️ 125 readers checked head CTs for intracranial #haemorrhage (randomised crossover). 😬, there was over reliance on wrong AI advice & under reliance on correct advice! Nonetheless, explainable AI improved diagnosis vs no AI (OR 1.84, 95% CI 1.49 to 2.28).
133530 - Prof Chris P Gale@cpgale3#aorticstenosis #MedEd The 2025 ESC/EACTS guideline recommends #TAVI for people aged 70 or over with tricuspid aortic valve stenosis & suitable anatomy (previously 75) & surgical valve replacement for those under 70 at low surgical risk, guided by the Heart Team. #cardiotwitter
0411478 - Prof Chris P Gale@cpgale3#SGLT2 meta analysis @JAMA_current Across 85 RCTs of 70,543 people with #heartfailure, CVD, #diabetes or CKD, SGLT2 inhibitors were associated with a small rise in haemoglobin vs control: difference 0.60 g/dL (95% CI 0.55 to 0.66). 🤔, haemoconcentration?
0511555 - Prof Chris P Gale@cpgale3#heartfailure #MedEd The 2026 ESC guideline gives a Class I recommendation for a mineralocorticoid receptor antagonist (MRA) in symptomatic #heartfailure whatever the ejection fraction. A steroidal MRA is advised in HFrEF & steroidal or nonsteroidal MRA in HFpEF. #cardiotwitter
16241.3K - Prof Chris P Gale@cpgale3#RELATIVITY047 RCT @NatureMedicine In 714 patients with advanced #melanoma, nivolumab plus relatlimab vs nivolumab improved overall survival, HR 0.78 (95% CI 0.64 to 0.95), & progression free survival, HR 0.77 (95% CI 0.65 to 0.92), at a minimum 57.3 months of follow up.
033452 - Prof Chris P Gale@cpgale3#Magnesium supplementation in non-acute #cardiovascular disease ▶️ I’m not aware of any adequately powered RCT for hard clinical endpoints.
137526 - Prof Chris P Gale@cpgale3Prof Chris P GaleRT @JACCJournals: 💊 Can SGLT2 inhibitors improve outcomes in transthyretin cardiac #Amyloidosis? A #JACCAdvances meta-analysis of 14 observational studies (n=10,852) found #SGLT2i use was associated with 56% lower all-cause mortality & 38% lower HF hospitalization.043013
- Prof Chris P Gale@cpgale3Prof Chris P GaleRT @TheLancet: Use of an AI chatbot ahead of GP appointments required no safety interventions in first real-world small study. However, authors caution that this study doesn't suggest AI chatbots are able to diagnose or triage patients without a doctor's oversight. 🔗022010
- Prof Chris P Gale@cpgale3Blustery, but good to get out. Tomorrow looks rather spicy.
Prof Chris P Gale @cpgale3000302 - Prof Chris P Gale@cpgale3Prof Chris P GaleRT @Channel4News: The London mayor Sadiq Khan has hailed what he called the end of two decades of decline for the capital's main shopping street as a large stretch of Oxford Street became fully pedestrianised. Bus stops and taxi ranks have been dismantled and future plans include planting trees and creating public squares, at a total cost of around £150 million.062014
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