David Sinclair✓
@davidasinclair
Professor researching why we age & how to reverse it. Author & host of Lifespan. Mission: Extend healthy life for all. Views are entirely his own. @joinlifespan
1.2K Following666K Followers11.2K Posts
- Couldn’t agree moreJon Del Arroz | Sci-Fi And Fantasy @jondelarrozWe must ensure Shatner lives forever, whatever it takes.173154827.4K
We must ensure Shatner lives forever, whatever it takes.
77801.1K33K- David SinclairRT @davidasinclair: Big congratulations to Dr. Christoph Gorgulla @StJude, a Lifespan Foundation Laureate, with a check for $100K to study AI-mediated drug design using quantum Thank you to subscribers of LS Magazine, who help support the Lifespan Foundation & research like Christoph's 🙏011030K
- Fertility echo means it takes 20-25 years to recover an economy once birth rates are restored - and that’s not going to happen for decades, if ever It’s an unmitigated social and economic disaster for Japan and Europe. Only hope is androids + longevityElon Musk @elonmuskSo many cultures are dying out74741.1K42.2K
- Wow: 41% of people polled think “our limited lifespan is good” I expect my father, Andrew - who at 87 is fit, disease-free, a true friend of his 5 grandkids & the happiest, most active physically and socially he’s ever been - would disagree
Michael Levin @drmichaellevinPoll: consider A: I believe our limited lifespan is good because finitude gives our life beauty and meaning B: I would be sad if the modern human embodiment went extinct and was replaced by something else1062057439.7K 
Poll: consider A: I believe our limited lifespan is good because finitude gives our life beauty and meaning B: I would be sad if the modern human embodiment went extinct and was replaced by something else1142317052.7K- David SinclairRT @JoinLifespan: The heart, kidneys and lungs already work harder to handle stress as we age. Now a hotter, more polluted and more unpredictable world is making their job even harder0604.2K
- A few more challenging steps left Your Senomune looks good 👏Dr. Thomas Ichim @exosomeThere is no scientist who has done as much as Dr. David Sinclair to bring the biology of aging into mainstream scientific discussion and give us a real shot at longevity escape velocity ! @davidasinclair is THE GOAT !71525621.2K
There is no scientist who has done as much as Dr. David Sinclair to bring the biology of aging into mainstream scientific discussion and give us a real shot at longevity escape velocity ! @davidasinclair is THE GOAT !221825642.6K- Thx. Working on it & won’t quit. Medicines are the most difficult, regulated of all products & aging is the most complex phenomenon in the universe. New ER-100 results are encouraging tho 🙏Jon @Jon49583047@exosome @davidasinclair I can't agree more but lets be clear. He has not brought anything to market worth while. Hopefully that will all change with what he is working on now.142039827.3K
Jon@Jon49583047Posts @exosome@exosome @davidasinclair I can't agree more but lets be clear. He has not brought anything to market worth while. Hopefully that will all change with what he is working on now.211420.4K- David SinclairRT @JoinLifespan: Could your high-protein diet be working against longevity? Protein helps protect muscle, but eating more isn’t always better for long-term health. Learn about the trade-offs between protein, muscle and lifespan0504.7K
- Surprised @TheLancet published such unscientific polemic. This on the heels of the new ER-100 results reminds me of when @NYT predicted powered flight could take a million yrs, just 69 days before the Wright brothers flew. “Several renowned experts told me” is what people write when they lack evidence. Expect more articles from the establishment as we make progress. People often fear what they don’t understand. ICYMI: “There are two delusions driving the world of longevity: the first is that ageing in humans is as malleable, or plastic, as it is in roundworms, fruit flies, and mice. The human body, the product of millions of years of evolution, is not, as our tech overlords believe, a programmable dataset. Several renowned biogerontologists told me that a significant biotech mediated expansion of human lifespan is unlikely in the foreseeable future: the longevity industry is a goldrush without gold. The second delusion is that longevity is primarily a scientific, or medical, concern. It is not.” 🙈João Pedro de Magalhães @jpsenescence"The longevity industry exists to exploit humanity, not to save it." - Seamus O'Mahony writes @TheLancet Or, as he puts it, "the longevity industry is a goldrush without gold." Talk about throwing out the baby with the bathwater! Of course, the field is drowning in hype and commercial interests pushing unproven interventions. But that doesn't detract from the fact that slowing human aging - even if slightly - would have enormous health and medical benefits. Manipulating human aging may prove harder than many in the field currently promise. But aging is no doubt malleable, so let's not lose sight of the field's long-term transformative potential. The challenge is to tell hype from science, not to dismiss the science because of the hype.494456737.6K
"The longevity industry exists to exploit humanity, not to save it." - Seamus O'Mahony writes @TheLancet Or, as he puts it, "the longevity industry is a goldrush without gold." Talk about throwing out the baby with the bathwater! Of course, the field is drowning in hype and commercial interests pushing unproven interventions. But that doesn't detract from the fact that slowing human aging - even if slightly - would have enormous health and medical benefits. Manipulating human aging may prove harder than many in the field currently promise. But aging is no doubt malleable, so let's not lose sight of the field's long-term transformative potential. The challenge is to tell hype from science, not to dismiss the science because of the hype.241711542.6K- It’s a privilege to get cancer. Not everyone gets to get cancerLancesico 🇱🇨 @BornakangCameron Diaz said, "There's no such thing as anti-aging. We're all aging, period... It's a privilege to get older, not everybody gets to get older."6751012.1K228K
Cameron Diaz said, "There's no such thing as anti-aging. We're all aging, period... It's a privilege to get older, not everybody gets to get older."
11883813.2K452K- David SinclairRT @JoinLifespan: Peptides are everywhere, but “peptide therapy” can mean anything from an FDA-approved medicine to an untested vial labeled “For Research Use Only.” What do we actually know about the compounds people are injecting?0604.4K
- Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent mannerJesse Morse, M.D. @DrJesseMorseFor NAD+ users: NMN and NR didn't extend lifespan here, and the NIH's ITP found the same for NR. Small arms, so not the last word. But there's still no good evidence that NAD+ precursors extend mammalian lifespan. An important note to make.313557477.3K
Posts @DrJesseMorseFor NAD+ users: NMN and NR didn't extend lifespan here, and the NIH's ITP found the same for NR. Small arms, so not the last word. But there's still no good evidence that NAD+ precursors extend mammalian lifespan. An important note to make.422171.6K- TrueMarcos Arrut @MarcosArrutRejuvenation without the loss of cellular identity. That is the fundamental problem of cellular reprogramming. Once solved, anti-aging biology will usher in the brightest era in human history. That's all.122951334.8K
Rejuvenation without the loss of cellular identity. That is the fundamental problem of cellular reprogramming. Once solved, anti-aging biology will usher in the brightest era in human history. That's all.132332633.5K- WoohooLife Biosciences @lifebiosciencesProud to be named one of @Fortune’s Best Workplaces in BioPharma 2026! This recognition reflects the people behind our mission and the collaborative culture driving our work to advance epigenetic restoration to reverse diseases of aging. View the list here:2616324.6K
Life Biosciences@lifebiosciencesProud to be named one of @Fortune’s Best Workplaces in BioPharma 2026! This recognition reflects the people behind our mission and the collaborative culture driving our work to advance epigenetic restoration to reverse diseases of aging. View the list here:232717.9K- YupChubby♨️ @kimmonismusNext step: Longevity and Rejuvenation. We are almost there. Researchers in Bonn turned blood cells from an 80-year-old into neural stem cells with a molecular age below 20. More than 60 years younger by epigenetic clocks, which estimate age from chemical marks on DNA. The team directly reprogrammed blood precursor cells into neural stem cells, skipping the usual pluripotent stem cell stage. The rejuvenation unfolded gradually and could be tracked for over 100 days.291431.9K79.8K
Next step: Longevity and Rejuvenation. We are almost there. Researchers in Bonn turned blood cells from an 80-year-old into neural stem cells with a molecular age below 20. More than 60 years younger by epigenetic clocks, which estimate age from chemical marks on DNA. The team directly reprogrammed blood precursor cells into neural stem cells, skipping the usual pluripotent stem cell stage. The rejuvenation unfolded gradually and could be tracked for over 100 days.
763182.8K189K- Never thought to squeeze a cellProf Steve Horvath @prof_horvathSqueezing a fibroblast nucleus for a moment opens chromatin at mappable loci. Yang Song and Song Li at UCLA aimed CRISPRa guides at exactly those spots. Fibroblast to neuron conversion went from under 3% to about 40%, with no virus. In aged mouse fibroblasts, the same mechanically enhanced Oct4 activation lowered DNA methylation age on the mouse skin clock, close to the level of cells from young animals. But global methylation also drops. so how much of this is rejuvenation rather than dilution is the open question. Title: Mechano-epigenetic enhancement of CRISPR activation of target genes fo…82938042.8K
Squeezing a fibroblast nucleus for a moment opens chromatin at mappable loci. Yang Song and Song Li at UCLA aimed CRISPRa guides at exactly those spots. Fibroblast to neuron conversion went from under 3% to about 40%, with no virus. In aged mouse fibroblasts, the same mechanically enhanced Oct4 activation lowered DNA methylation age on the mouse skin clock, close to the level of cells from young animals. But global methylation also drops. so how much of this is rejuvenation rather than dilution is the open question. Title: Mechano-epigenetic enhancement of CRISPR activation of target genes fo…72819847.7K- David SinclairRT @JoinLifespan: Bowhead whales can live for >200 years - longer than any other known mammal on earth! 🐳 Enjoy more science cartoons in Lifespan Magazine:0304.4K
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