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Daniel Ives
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Daniel Ives✓

@dives86

Vitalist CEO @ShiftBioscience

  • Cambridge
  • Joined
187 Following1.5K Followers639 Posts
  1. Daniel Ives✓@dives86
    Daniel Ives
    RT @teleodaniel: Twenty years ago, @DeryaTR_ predicted we would reverse aging by 2045. People thought he was crazy. Now, he thinks he was too conservative, and has moved the date up to 2040 because AGI arrived earlier than he expected. I sat down with Derya to ask if such bold predictions are too fatalistic. Is the future guaranteed? Shall we just sit back and wait for AI to save us? Derya disagreed. The golden age for humanity is within our sights, but there is much work to be done. Academia is failing us. If it doesn’t adapt to the pace of progress AI enables, we have no shot at curing aging this century. And we need to invest trillions into collecting the data that superintelligence will need to solve biology. If we pull it off, the future can be brighter than anyone imagines. Watch the full episode below, or look up Free Radicals (@FreeRadicalsBio) on your favorite podcasting platform. Special thank you to @adamgries and for hosting us at @VitalistBay! Intro AGI arrived early, accelerating the timeline to biosingularity Are we really in the takeoff now? Superintelligence can help us build a world model of biology Aging as the breakdown of biological resilience The case for investing trillions into biological data The economic return on curing aging AI is accelerating science but academics are stuck in the past How AI can liberate humanity from biological constraints Derya’s Human 2.0 dream Testing the latest OpenAI models and rethinking the PhD Agency, jobs, and free will in an AI world Science fiction & Derya’s case for a coming golden age
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  2. Daniel Ives✓@dives86
    Daniel Ives
    RT @realNathanCheng: 1/ How long do you want to live? For most of human history, aging was inevitable. It's now solvable. Apply for LBF8 cohort program: longbiofellowship dot org /THREAD🧵
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  3. Daniel Ives✓@dives86
    Daniel Ives
    RT @teleodaniel: “You’re born, you grow up, you have a career, and then you get older and then you die. And that's just like the acceptable plan. Even if the plan is horrible… as long as we're going to plan, everybody goes along with it.” @realNathanCheng is one of the most prolific activists in the longevity field. He argues that aging, decline and death are not really a great plan, even if it's the way things work today. He has dedicated his life and career to finding us a new plan. Follow me and @EricDai_BioE to stay up to date on the latest news in longevity biotech! 0:00 Intro 2:35 Why did Nathan dedicate his life to defeating aging & death? (And the absurdity of asking that question) 8:59 Why has Daniel been on the fence, despite being longevity-pilled 14:09 The agency and bravery of founders to tackle the hardest problems (like aging) 18:46 Many ways to contribute to longevity besides entrepreneurship 19:41 Is longevity underinvested into? 24:48 What does it mean to treat aging itself as the issue (vs other diseases) 32:23 Do we need more scientific arguments, or philosophical arguments? 39:50 Nathan’s experience longevity-pilling influential people 47:03 Billionaire paradox 53:18 The challenge in going from viewing aging as inevitable to malleable 57:29 What needs to change about our culture to save us from aging & death 1:16:55 Should we be intolerant of pro-death & pro-aging views? 1:22:59 Join us at Vitalist Bay!
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  4. Daniel Ives✓@dives86
    Daniel Ives
    RT @prof_horvath: Single-cell epigenome atlas identifies kidney epithelial cells as a driver of epigenetic aging. Lake et al. (2026) build a cross-species atlas showing that aging is driven by collapse of 3D chromatin structure in tubular epithelia. Beautiful multi-omic work.
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  5. Daniel Ives✓@dives86
    Daniel Ives
    RT @BoWang87: Crows discovered antibiotics millions of years before humans. When a crow gets sick, it does something that looks insane — it finds an ant colony and deliberately pisses them off. The ants attack. They spray formic acid everywhere in defense. The crow? Doesn't run. It spreads its wings and just... takes it. Lets the ants crawl all over its body. Here's the genius part: Formic acid is a natural antibacterial and antifungal compound. It kills the parasites and microbes that destroy feathers. The crow is basically giving itself a chemical bath. Scientists call this "anting." Over 200 bird species do it. First documented in 1831, but birds have been doing it for millions of years. It gets weirder. When ants aren't available, some birds grab LIT CIGARETTE BUTTS and rub themselves with the smoke instead. They found a substitute for their medicine. We spent centuries "discovering" antibiotics. Crows were running their own pharmacy this whole time. Here's what strikes me: evolution is the original drug discovery engine. Billions of years. Trillions of experiments. No hypothesis — just relentless trial and error until something works. Now we're building AI systems that do the same thing for antibody design — searching vast molecular spaces, predicting protein structures, optimizing binding affinity. What took nature millions of years, AI can explore in days.
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  6. Daniel Ives✓@dives86
    Daniel Ives
    RT @KarlPfleger: Last week my shortest podcast interview dropped (Decoding Longevity). This week here's my longest just out (Free Radicals). Great wide-ranging conversation covering the aging biotech sector & companies getting to approvals but also how to think about stuff available now.
    Daniel Shur @teleodaniel
    For our 10th episode of the Free Radicals podcast, @EricDai_BioE and I are excited to host @KarlPfleger After a decade as one of the first AI researchers at Google from 2002 to 2011, Karl dedicated himself to the cause of rejuvenation biotechnology. He is a philanthropist, community builder, and prolific angel investor with over 35 investments into rejuvenation biotech startups. His website, provides valuable information to the entire field, and his talks and X posts are highly insightful and influential within longevity. Karl has deeply researched and nuanced takes, and those really show in this conversation. We cover why epigenetic reprogramming won’t solve aging, Karl’s investment strategy, what distinguishes true rejuvenation technology, why better diagnostic technologies could be the key to personalized aging interventions, and much more. Special thank you to @NFX & @omri_drory for lending us their beautiful podcasting studio! 0:00 Intro 1:56 Peter Attia and defining longevity 8:37 What is aging? 12:41 Wear and tear vs programmed obsolescence 16:12 Which molecular mechanism of aging do we have the most control over? 19:29 Does partial reprogramming solve the whole aging problem? 25:23 How to identify truly rejuvenating therapies 32:35 The role of AI and good screening technologies 37:03 Do we understand the mechanisms of aging well enough to intervene? 38:39 Will there be a longevity tipping point? 44:51 Karl's investment strategy for aging biotech 52:21 Senolytics 1:01:33 Misfolded protein clearance & mitochondrial transplantation 1:08:21 Sauna & parabiosis (not combined) 1:15:54 Stem cell therapies 1:22:02 Karl's research process & formal techniques for evaluating arguments 1:28:55 The successes of the geroscience paradigm 1:34:13 Diagnostic bottlenecks
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  7. Daniel Shur✓@teleodaniel
    For our 10th episode of the Free Radicals podcast, @EricDai_BioE and I are excited to host @KarlPfleger After a decade as one of the first AI researchers at Google from 2002 to 2011, Karl dedicated himself to the cause of rejuvenation biotechnology. He is a philanthropist, community builder, and prolific angel investor with over 35 investments into rejuvenation biotech startups. His website, provides valuable information to the entire field, and his talks and X posts are highly insightful and influential within longevity. Karl has deeply researched and nuanced takes, and those really show in this conversation. We cover why epigenetic reprogramming won’t solve aging, Karl’s investment strategy, what distinguishes true rejuvenation technology, why better diagnostic technologies could be the key to personalized aging interventions, and much more. Special thank you to @NFX & @omri_drory for lending us their beautiful podcasting studio! 0:00 Intro 1:56 Peter Attia and defining longevity 8:37 What is aging? 12:41 Wear and tear vs programmed obsolescence 16:12 Which molecular mechanism of aging do we have the most control over? 19:29 Does partial reprogramming solve the whole aging problem? 25:23 How to identify truly rejuvenating therapies 32:35 The role of AI and good screening technologies 37:03 Do we understand the mechanisms of aging well enough to intervene? 38:39 Will there be a longevity tipping point? 44:51 Karl's investment strategy for aging biotech 52:21 Senolytics 1:01:33 Misfolded protein clearance & mitochondrial transplantation 1:08:21 Sauna & parabiosis (not combined) 1:15:54 Stem cell therapies 1:22:02 Karl's research process & formal techniques for evaluating arguments 1:28:55 The successes of the geroscience paradigm 1:34:13 Diagnostic bottlenecks
    Download
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  8. Daniel Ives✓@dives86
    Daniel Ives
    RT @teleodaniel: This week, we are excited to welcome @dives86 onto the Free Radicals podcast! Dr. Daniel Ives is the founder of @ShiftBioscience. Shift has built a novel single-cell aging clock that has enabled them to run high-throughput screens to discover genes that regulate aging, with the goal of identifying a therapy to systemically reverse aging. They’ve raised $16M from investors like Business Growth Fund, @FPrimeCapital, and @Kindred_VC to pursue this mission. In this episode, we discuss Shift’s formation and their approach, and dive deep into two promising targets they’ve discovered, as well as the coming cultural shift when anti-aging drugs become mundane reality. Be sure to follow @FreeRadicalsBio and @EricDai_BioE for weekly episodes about longevity biotech! 0:00 Intro 1:37 Deciding to work on aging 5:52 Origins of Shift Bioscience 9:54 Role of mitochondria in aging 13:03 Aging clocks & the meeting that led to XPRIZE Healthspan 18:11 Cracking the single cell aging clock 21:45 The accuracy and role of aging clocks 27:28 A single gene that reverses cellular age 36:59 Engineering small molecules for age reversal 43:07 How virtual cells accelerate scientific progress 49:55 From virtual cell to virtual human? 56:54 Asking the right questions 01:07:57 Backup plans 01:10:43 Lightning round
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  9. Daniel Ives✓@dives86
    Daniel Ives
    RT @adamgries: 🧵 Elon: “Longevity is an extremely solvable problem” At Vitalist Bay (May 14 - May 17), we’re solving it! 1K+ pioneers, 100+ speakers, 50+ workshops, 40+ activities, 5 critical health tests Join us to spark dozens of SpaceXs for longevity!
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  10. Daniel Ives✓@dives86
    Daniel Ives
    RT @antonioregalado: Here's the story. Sinclair showed in 2020 that mice whose eye nerves were "reprogrammed" regained vision after an eye crush injury. Now, basicially the same technology is going to be used in human
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  12. Daniel Ives✓@dives86
    Daniel Ives
    RT @AlexHormozi: Everything you want is on the other side of difficulty, uncertainty and delay. Hard problems - that you don't know how to solve - on a timeline you aren't sure you're going to solve them in - all while being unsure if all this will have been for nothing.
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  13. Daniel Ives✓@dives86
    Daniel Ives
    RT @JellyfishDAO: What if our descendants look back at our acceptance of aging the way we look back at medieval medicine? We interviewed them. Dystopian futures are easy to imagine. Optimistic futures take vision and courage to build. VOICES FROM 2099:
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  14. Daniel Ives✓@dives86
    Daniel Ives
    RT @teleodaniel: Today I am launching the Free Radicals podcast with @EricDai_BioE . Every Tuesday, we’ll be releasing long form conversations with the visionaries giving humanity control over biology and working to dramatically extend human lifespan. We’re thrilled to host @celinehalioua, Founder + CEO @loyalfordogs, for our inaugural episode. Celine is building the world’s first lifespan extension drugs for dogs. Follow me, @EricDai_BioE and @FreeRadicalsBio for new episodes every Tuesday. 00:00:00 - Intro 00:01:51 - Celine’s background 00:05:00 - Dropping out of academia 00:07:50 - Finding ways to increase free will 00:09:36 - How to align financial incentives with longevity 00:14:52 - Longevity drugs should be boring 00:21:24 - Celine’s leadership style 00:24:08 - Advice on fundraising and constructing feedback loops 00:26:52 - Loyal’s fundraising history 00:27:57 - Building for Zero Billion Dollar Markets 00:29:11 - How to succeed in biotech 00:30:21 - How to find blockbuster opportunities 00:33:25 - How to create a gold rush in longevity 00:35:25 - The problem with the aging field 00:39:32 - How to identify signal from noise 00:41:54 - AI applications to biology 00:45:15 - Importance of naiveté 00:47:24 - FREE RADICALS
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  15. Daniel Ives✓@dives86
    I'm excited to be speaking at @RNID's Hearing Therapeutics Summit 2025, which is helping to speed the development of therapeutics for hearing loss and tinnitus. With a strengthening link between age related hearing loss and the underlying aging process, hearing loss has become a new test bed for cellular rejuvenation gene therapy. Find out more about the programme
    Download
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  16. Daniel Ives✓@dives86
    Daniel Ives
    RT @DeryaTR_: ‘Healthy aging’ is an oxymoron! That notion must end! If your biology were perfectly healthy, you would not age. This slogan has severely narrowed the scope of aging research & longevity priorities & has been harmful to genuine efforts for targeting root causes to reverse aging.
    Buck Institute @BuckInstitute
    🎬 Exciting news! Buck donor James B. Johnson, MD is producer of new film Forever Young, features groundbreaking work of Buck scientists and others advancing future of healthy aging. We’re thrilled to share that film has been officially selected by @MVFilmFest! @TheAgingDoc
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  17. Buck Institute@BuckInstitute
    🎬 Exciting news! Buck donor James B. Johnson, MD is producer of new film Forever Young, features groundbreaking work of Buck scientists and others advancing future of healthy aging. We’re thrilled to share that film has been officially selected by @MVFilmFest! @TheAgingDoc
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  18. Daniel Ives✓@dives86
    Daniel Ives
    RT @AlexHormozi: Criticism is a fixed cost of taking action. People will criticize you if you anything note worthy. They’ll also criticize you for doing nothing. So you might as well just do what you want.
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  19. Daniel Ives✓@dives86
    Daniel Ives
    RT @GusDomel: Who is looking for $500k in Bio?? Apply now for the @BoostVC Residency!
    Adam Draper ⏻ @AdamDraper
    I believe that the startups that will cure cancer, enlongate life 50 years and give humans super powers are starting today! So we are launching a Bio Residency @BoostVC to bring the best builders in Bio together! APPLY NOW!!!!
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  20. Adam Draper ⏻✓@AdamDraper
    I believe that the startups that will cure cancer, enlongate life 50 years and give humans super powers are starting today! So we are launching a Bio Residency @BoostVC to bring the best builders in Bio together! APPLY NOW!!!!
    82111746.9K
  23. Daniel Ives✓@dives86
    Daniel Ives
    RT @ARPA_H: NEW: No technology currently exists to repair damaged brain tissue and fully restore lost function. FRONT aims to enable millions with what is considered permanent brain damage to regain lost functions, including motor control, vision, and speech.
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  24. Daniel Ives✓@dives86
    Daniel Ives
    RT @wilstc: What is the state of research on the emerging grand challenge of virtual cell modeling? 1/n
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