#ADCS

#ESMO26: Changing the cytotoxic payload may help to overcome resistance to antibody–drug conjugates (#ADCs). @RachelAbelman discusses studies investigating this strategy to improve patient responses in #BreastCancer. #InsightsbyESMO ➡️

If you manage #ActiveDirectory or #PKI, take an easy win by running @dotdotdotHorse's Locksmith script. "Identify and remediate common misconfigurations in Active Directory Certificate Services." I found and fixed a few! #ADCS 🔍

Grab the fresh release of Locksmith to help secure your Active Directory Certificate Services in 2025! This free tool now includes risk ratings and other improvements. Install-Module Locksmith -Scope CurrentUser #ActiveDirectory #ADCS #PKI #PowerShell

Check out this recent systematic review and meta-analysis of neoadjuvant #AntibodyDrugConjugates for early-stage breastcancer. 🔓 @ruiz_simoes @RafaelLaraNohmi @PTarantinoMD #ADCs #eBC #BreastCancer

Locksmith 2024.10 is out with quality updates and improved detections for ESC8 and ESC3 condition 2. Have you double-checked your Active Directory Certificate Services templates yet? #ADCS #PKI #WindowsServer #ActiveDirectory #PowerShell

Excellent overview of advances of #ADCs in #NSCLC and #SCLC by @JuliaRotow of @DanaFarber and @stephanieplsaw of @NCCS_SG at @CUHKMedicine #IOHK26 in #HongKong 🇭🇰 @apoddc @APCLC_2023 #LCSM @IASLC

Have you checked your Active Directory Certificate Services for insecure template configs? 🔐 The Locksmith #PowerShell module just got updated with some more cake and a bit of tasty icing! #ADCS Install-Module Locksmith Release Notes:

SecureAuth #Impacket 0.9.24 is now available. Discover the new features including ways to dig deeper into #ADCS, a more hardened #SMB server and delegation features. Read the blog by @0xdeaddood: #offensivehacking

Silanna Targets #EdgeAI with High-Performance Compact #ADCs #PluralNano

🚨 A public PoC has been released for CVE-2026-54121 affecting Microsoft Active Directory Certificate Services (AD CS). The vulnerability allows an authorized attacker to escalate privileges over the network. 🔗 #Microsoft #ADCS #PrivilegeEscalation

Happy to share our @AACR Cancer review of #ADCs in #GynecologicCancers #gyncsm 📍From approved ADCs to those on development ❗Resistance & sequencing ⏩ Toxicity management Free access 👇 @ArantzazuBarqu1 @LKasherman @StephanieLheur5 @OncoAlert

A new case study in the Lens Library explores resistance mechanisms to #ADCs in patients with urothelial cancer. Using real-world data in Tempus Lens, researchers analyzed more than 1,300 patient records to identify genomic and transcriptomic markers of ADC response. The analysis revealed key molecular distinctions between responders and non-responders, providing insights that can help life sciences companies: ◾Refine inclusion criteria for future clinical trials ◾Develop rational combination strategies ◾Inform the design of next-generation therapeutics Access the full study in the Lens Library here:

I told you #ADCS should be considered as Tier0 and as sensitive as Domain Admins and Domain Controllers. Check this out to know more!

▶ Microsoft #ADCS - Abusing #PKI in Active Directory environment ◀ I've been bragging about it for months, this is the result of many weeks of work on lesser known compromise paths for #pentest by using enterprise PKI. Feedback is highly appreciated!

Chemotherapy-induced peripheral neuropathy remains a major challenge in clinical practice, particularly in the era of #ADCs. This comprehensive #review provides an overview of the underlying mechanisms and emerging management strategies. @sundar__raghav

Hacked employee? No malware, no zero-day. Just a Teams call that looked like IT. 👉 Full breakdown: #MicrosoftTeams #ADCS #CyberSecurity #InfoSec #SocialEngineering #ThreatIntelligence

Sit in on our chat with Beth Sandy, MSN, CRNP, FAPO (@BethSandy), at #JADPROLive to hear her thoughts on real-world biomarker testing gaps in #LungCancer and how nurse practitioners and physician associates can prepare for the next wave of progress with #ADCs. Watch now:

ADCS misconfigs are an attacker’s dream. My new post covers every major ADCS attack (ESC1-16) with code from real pen tests and GOAD lab, privilege escalation & persistence made easy. #ActiveDirectory #RedTeaming #ADCS

🚨 If you haven’t patched your AD CS servers yet, now is the time. A public PoC for Certighost (CVE-2026-54121) is now available. #certighost #ADCS #activedirectory #redteaming

🌟Just ahead of #WCLC26, an exquisite cutting-edge Review in @JTOonline on #ADCs in #SCLC by amazing author group @fede_monaca @MuskuAgarwal @StephenVLiu @LuisPaz_Ares and @caliraf A must-read for every SCLC-warrior exemplifying that the combination of #TCEs and #ADC holds promise for deep and durable responses in ES-SCLC @SclcSMASHERS @lcsmchat @LungCancerEu @LUNGevity @YoungLungCancer @lcfamerica

From @myESMO advanced course on #ADCs meet the new kids on the block: ✅ Bi-specific/Bi-paratopic ADCs ✅ PDCs with peptide masks allowing payload cleavage by tumor proteases ✅ ISACS with TLR or STING agonist payload ✅ DACs degrading target through proteasome ubiquitin #LCSM #some @OncBrothers @OncoAlert @VJOncology @MedscapeOnc @oncodaily @HeSMO_X