#ISC24

ZODIAC trial examining the effect of Head of Bed at 0 vs 30 degrees pre-EVT, just announced during the #ISC24 NIHSS worsening 2+ points - 0 degrees: 2% - ⁠30 degrees: 55% Benefit persists thru discharge; Non-significant mRS 0-2 differences at 90 days

ZODIAC trial examining the effect of Head of Bed at 0 vs 30 degrees pre-EVT, just announced during the #ISC24 NIHSS worsening 2+ points - 0 degrees: 2% - ⁠30 degrees: 55% Benefit persists thru discharge; Non-significant mRS 0-2 differences at 90 days

#STROKE In a post hoc analysis of the RESIST trial, patients with stroke of small vessel etiology exhibited a benefit with respect to remote ischemic conditioning over sham, under a per protocol framework. #ISC24 #AHAJournals @rablauenfeldt @clauszsimonsen

STEM Trial: SQUID for Treatment of Chronic Subdural Hematoma presented by @AdamArthurMD at #ISC24 310 Patients randomized. 1⁰ Endpoint Re-accumulation of the SDH on 180-day: 39.29 vs 15.2% favoring MMA embolization. OR 3.60(1.91-6.78) p=0.0001 The future is bright.

Are you RESILIENT-2? EVT late window in Brazil shows massive benefit of CT/A selected treatment especially in pts <68 yr, but ⬆️ rates of good outcome (mRS 0-2) at expense of ⬆️ rates of survival with major disability. No ⬆️ ICH. #ISC24 @AHAScience WOW 😯

EMBOLISE Trial: Surgical Cohort results announced at #ISC24 MMA embolization with Onyx led to a 3-fold reduction in recurrences requiring surgical drainage compared to Surgery Alone - per CEC adjudication (4.1% vs 11.3%, p=0.0081). NNT14! #ISC24

🔥 #ISC24 trials: quick summary 👇🏻👇🏻

J Saver DMeVO #ISC24 @StrokeAHA_ASA

#ISC24 Final results STOP-CAD in patients with cervical artery dissection are out. Anticoagulation with non-significantly lower ischemic stroke risk but higher bleeding risk if cont’d up to 180 days. Occlusive dissections did better with anticoagulation.

Head of bed FLAT for LVO! Early improvement HIGHER for pts laid flat versus 30 degrees with NO signal of harm in ZODIAC trial @AHAMeetings #ISC24 No benefit in functional outcome at 90d although there was a trend for improvement. Sample NOT powered for long term analysis!

Dr Saver from @UCLAStrokeNeuro reviews PFO closure at #ISC24 1) PASCAL criteria for PFO closure, not just ROPE score (look at shunt size, septal aneurysm >10mm) 💔 2) Can have afib after procedure. 🩺 3) Consensus criteria for rhythm monitoring prior to closure ⚡️

In patients with cryptogenic stroke and evidence of atrial cardiopathy without atrial fibrillation, apixaban did not significantly reduce recurrent stroke risk compared with aspirin. #ISC24

ZODIAC trial finds that the safest HOB is 0 degrees @AnneAlexandrov #ISC24

#ISC24 @StrokeAHA_ASA The EMBOLISE Study: Embolization of the Middle Meningeal Artery With OnyxTM Liquid Embolic System in the Treatment of Subacute and Chronic Subdural Hematoma NNT = 14 NO SAFETY CONCERNS

Should AD patients receive amyloid immunotherapy if their MRI shows microbleeds? What if they are anticoagulated for Afib? Topics on the table for the Feb 9 ISC symposium "ARIA: Vascular Manifestations of Amyloid Immunotherapy" #ISC24 @AHAScience

The STOP-CAD study comparing antithrombotic regimens in cervical artery dissection was submitted as a late breaking abstract to the International Stroke Conference. We are very grateful for the 63 contributing sites worldwide! Register for #ISC24 🛑CAD

After working to onboard initial members and projects for the past 6 months, we’re excited to start building #HPSF! Don’t miss our #ISC24 BOF today at 1pm. Christian Trott and I will be talking about plans and looking for feedback from all of you! #HPC

We are excited to announce the launch of the High Performance Software Foundation (HPSF), to build, promote, and advance a portable core software stack for high performance computing. Read the announcement: #hpsf #hpc #opensource

Game of Strokes in full swing at #ISC24 My money is on the blue team @amrsarrajMD @AmeerEHassan although lagging a bit behind ! @ShadiYaghi2 @yasmin @AHAScience

Article Commentary: “Effect of Remote Ischemic Conditioning in Ischemic Stroke Subtypes” In this new #BloggingStroke post, @angeljcadenaMD discusses #Stroke article by @rablauenfeldt et al., presented this week at #ISC24. @clauszsimonsen #AHAJournals

Remember, pregnancy is NOT a contraindication to IV thrombolysis or mechanical thrombectomy! #ISC24 @StrokeAHA_ASA #neurotwitter #meded