#ScienceSignaling

Don’t miss the new issue of #ScienceSignaling! New insights into Wnt signaling could inform the design of rational ligands for therapy, a Review discusses the latest discoveries about the origins of brain metastases and potential targets, and more.

A preclinical study uncovers a metabolic pathway that offers a target in neuropathic pain, scientists discover how chemokines can support red blood cell production in mice, and more this week in #ScienceSignaling.

This week’s new issue of #ScienceSignaling has arrived! Researchers discover how the inflammatory death of neutrophils drives a rare group of autoinflammatory disorders, a new study uncovers an “inside out” regulatory mechanism for a GPCR, and more.

This week’s new issue of #ScienceSignaling has arrived!

Don’t miss this week’s new issue of #ScienceSignaling! Scientists trace how an RNA-editing enzyme restrains a hallmark of aging in intestinal stem cells, our Editors’ Choice piece considers recent findings about how stress induces senescence, and more.

Don't miss this week's new issue of #ScienceSignaling!

Scientists discover memory-enhancing properties of acetate unique to female mice, a new Review explores the latest discoveries about metabolic reprogramming after traumatic nerve injury, and more this week in #ScienceSignaling.

Don’t miss this week’s issue of #ScienceSignaling! Scientists discover a targetable pathway that drives drug resistance in aggressive prostate cancer, a new structural analysis offers insight into the transcriptional regulator STAT1, and more.

The new issue of #ScienceSignaling has arrived!

This week’s new issue of #ScienceSignaling has arrived! A study reveals how fetal cells could activate maternal natural killer cells during early pregnancy, systems immunology reveals cytokine targets in ulcerative colitis, and more.

Researchers delineate how a pathway drives the growth of bone tumors in a painful inherited bone disorder, new experiments in mice show how an enzyme inhibits the leakage of calcium ions in skeletal muscle cells, and more this week in #ScienceSignaling.

This week’s new issue of #ScienceSignaling has arrived! A subset of lipid molecules can foster wound healing and protect mice from sepsis, research decodes how an ion channel clears out toxic amyloid proteins in a model of Alzheimer’s disease, and more.

This week’s new issue of #ScienceSignaling has arrived! A team identifies a gatekeeper of cartilage health that goes awry in osteoarthritis, a Review highlights how cell nutrition is emerging as a pillar of fitness for unconventional T cells, and more.

The new issue of #ScienceSignaling has arrived! Research in mice shows how microglia can trigger depressive-like behaviors linked to neuroinflammation, in vitro work reveals that adhesion GPCRs aren’t activated by corticosteroids, and more.

This week’s new issue of #ScienceSignaling is out! A long noncoding RNA offers a potential target in triple-negative breast cancer, mutual information uncovers pathways that underlie heterogeneity in pancreatic cancer, and more.

Scientists uncover a surprising connection between the brain’s maze of blood vessels and fine motor control in the cerebellum, new tools provide scientists with an optogenetic means to control G protein signaling, and more this week in #ScienceSignaling.

A molecular switch boosts cell migration and the invasiveness of brain cancer cells, discoveries about specific SMAD signals in T cells could guide autoimmune disease research, and more in the new issue of #ScienceSignaling.

A study reveals a tumor suppressor may also distinguish immune-sensitive kidney cancer tumors, researchers uncover an enzyme that facilitates the B cell immune response, and more in this week’s new issue of #ScienceSignaling.

This week’s new issue of #ScienceSignaling is here! Scientists identify a redox switch in plants that fine-tunes the plant immune system’s response to infections, a team discovers metastatic functions for a protein long assumed to be inactive, and more.

The new issue of #ScienceSignaling has arrived! This week, researchers combine two creative technologies into a tool that can deorphanize GPCRs and apply it to uncover a binding partner for the obesity-linked receptor GPRC5B.