Genes & Development@GenesDev
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RESEARCH PAPER: Sharp cell type boundaries emerge from coordinated morphogen signaling
By Li et al. and Peggy Myung
➡️
@Yale
#morphogen #WNT #Hedgehog #patterning
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Posts with #morphogen
#morphogen
Public posts on X that use #morphogen.
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Dagmar Iber@DagmarIberHow precise are noisy #morphogen gradients in #tissue #patterning? It turns out that the positional information they convey to #cells in the #neuraltube is much more accurate than previously estimated! Our new #devbio paper is out in @NatureComms:
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EMBO Reports@emboreports
Tsuyoshi Hirashima @hirashima0203Truly a fun collaboration with @SatoshiTodaLab and @Kosuke_Mizu on the SYMPLE3D project, now out in @emboreports! The synthetic biology approach led to the unexpected finding of gradient input resulting in sharp boundary output, demonstrated in 3D spheroids. A short 🧵 below:074711.4K
Tsuyoshi Hirashima@hirashima0203Truly a fun collaboration with @SatoshiTodaLab and @Kosuke_Mizu on the SYMPLE3D project, now out in @emboreports! The synthetic biology approach led to the unexpected finding of gradient input resulting in sharp boundary output, demonstrated in 3D spheroids. A short 🧵 below:2114816.1K
Kristina Stapornwongkul@KStapornwongkulHow to make a #morphogen? Find some answers in our paper (fresh from the press!) describing the transformation of GFP into a morphogen that can control growth and patterning of the Drosophila wing. #synbio #devbio1473253- Dagmar Iber@DagmarIber@DagmarIberIn the #neuraltube, progenitors need to take the right fate at the right time & place to build a functional nervous system. Opposing #morphogen gradients provide #positional information. But how do the cells know the time? Let’s look at gradients in growing tissues. 🧵(2/9)
102383 - Dagmar Iber@DagmarIberDoes self-enhanced #morphogen #degradation improve #patterning #precision in #tissue #development? Using a cell-based stochastic reaction-diffusion model, we now challenge this long-held view. Check out our latest pre-print: A short summary:🧵(1/8)
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Alfonso Martinez Arias@AMartinezAriasNodal as a (very) short range #morphogen new preprint from te always excellent @WarmflashLab . Follows earlier leads from C. Hill & raises questions @ what molecules can do v what they actually do in bio-systems #InNumbersWeTrust0325- Dagmar Iber@DagmarIberHow does an #embryo measure #time? It turns out that morphogen gradients can also act as timers. Check out our latest @biorxivpreprint : #development #morphogen #patterning #preprint #cells #tissue 👇Thread 🧵(1/9)3238114K
- Dagmar Iber@DagmarIber@DagmarIberOpposing #morphogen gradients (as found in the #neuraltube) can allow for #synchronised #timing along the entire #patterning axis with a single readout threshold. The product of their concentration profiles is uniform, but declines with time on growing domains. 🧵(7/9)
102270 - Dagmar Iber@DagmarIber@DagmarIberIn summary, #morphogen gradients can not only convey position, but also #time. Gradient-based timers can coordinate #cell #differentiation in space. Coupling with cell-intrinsic timers may yield transient responses also with constant activation - as observed in the #neuraltube.103474
- Dagmar Iber@DagmarIber@DagmarIberThe same duration along the patterning axis can be obtained via a position-dependent readout threshold for the #morphogen. The further away from the source, the lower the threshold needs to be - similarly to #patterning in space. 🧵(6/9)
102249 - Dagmar Iber@DagmarIber@NatureComms@NatureComms published a Matters Arising piece related to our work on the #precision of #morphogen #gradients in the neural tube, The criticism was easy to rebut: But:102624
- Dagmar Iber@DagmarIber@DagmarIberWe show that non-linear #morphogen decay slightly improves #patterning #precision close to the morphogen source, but the effect is minuscule. Far from the source, non-linear decay leads to imprecise gradients. 🧵(2/8)
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Sevi Durdu@biosevi🧬Preprint alert! FGF3 isn’t just a paracrine signal, it’s a self-editing morphogen. Fgf3-producing cells ignore parts of their own signal via nuclear repression of select target genes. A built-in asymmetry between senders and receivers! #FGF #Morphogen
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Turing patterns in time! Cells must differentiate according to their position within the whole (that's why my brain is just (barely) that). But how do they know *when*? Turns out that Turing patterns, which say 'where', in an expanding system, can code for 'when'. Great work!Dagmar Iber @DagmarIberHow does an #embryo measure #time? It turns out that morphogen gradients can also act as timers. Check out our latest @biorxivpreprint : #development #morphogen #patterning #preprint #cells #tissue 👇Thread 🧵(1/9)100637- Dagmar Iber@DagmarIber@RCG_Heretic@RCG_Heretic Thanks for the comment, but a small correction: it is not a Turing patterning mechanism, just normal #morphogen gradients with a threshold-based readout (French Flag model).106332
David Mörsdorf@DavidMoersdorfRecent paper by @rkharish93 uses a #zebrafish FGF8-EGFP knock-in to quantify its #morphogen gradient “providing a functional proof for the morphogenic action of endogenous Fgf8a, consistent with Wolpert's French flag hypothesis”03181.4K
PNASNews@PNASNewsJournal Club: How complex patterns from simple changes--Math #model shows how a single #morphogen can shape a system: #AlanTuring #CellularNetworks #GeneExpression
0274.2K- Dagmar Iber@DagmarIberHow does #cell size affect #patterning precision in the #embryo? A novel cell-based simulation framework reveals the impact of cell diameter on #morphogen gradient variability in #tissue #development. Check out our latest pre-print: 🧵 (1/6)
656175 - Dagmar Iber@DagmarIber@DagmarIberDifferent #readout #mechanisms result in similar gradient variability. Cell size has a far greater impact than #spatial #averaging. A bit of a surprise, no?
102 - Dagmar Iber@DagmarIber@DagmarIberThe positional error of #morphogen gradients increases with the square root of the mean cell diameter. #Narrow #cells lead to the highest absolute patterning #precision.
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Amoyel lab@AmoyelLabLovely paper published by @fernandesflylab who we share lab space with. An unexpected #morphogen gradient coming from an axon - check it out! Also congrats to Matthew Bostock who can start his postdoc in @CorinneHouart's lab with his PhD work published!2418
Dani Aguilar-Hidalgo@emergentcellHappy to share my latest paper with Frank Jülicher and @mgg_lab with @z_hvas and MRM “Dynamic modes of morphogen transport” See thread for details ⬇️⬇️⬇️⬇️⬇️⬇️⬇️4516- Dani Aguilar-Hidalgo@emergentcell@emergentcellHere, we discuss the mode structure of a #morphogen transport model allowing both passive and active transport of molecules.102
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