English
Matthias Mann Lab
Report

Matthias Mann Lab

@labs_mann

The Mann Lab is a pioneer in mass spectrometry-based proteomics. Tweets represent personal views from lab members and Matthias Mann @MPI_Biochem and @UCPH_CPR.

80 Following14.5K Followers755 Posts
  1. Matthias Mann Lab@labs_mann
    Matthias Mann Lab
    RT @GairdnerAwards: Yesterday, the 2026 Gairdner International Symposium brought together Gairdner laureates and leading researchers to explore how breakthrough discoveries translate into transformative therapies and shape the future of medicine. (1/2) #GairdnerScienceWeek
    01059
  2. Matthias Mann Lab@labs_mann
    Matthias Mann Lab
    RT @GairdnerAwards: Research and Response: Lessons for the future livestream starts at 11:30AM ET! Hear directly from Gairdner Laureates and leading researchers about the challenges of urgent health crises & the emerging threats facing the next gen of researchers. Join:
    01044
  3. Matthias Mann Lab@labs_mann
    Matthias Mann Lab
    RT @GairdnerAwards: The 2026 Laureate Lectures livestream starts at 9AM ET! Join us online to hear directly from the 2026 Canada Gairdner Award laureates as they share the science behind their discoveries. 🔴 Watch the livestream: #GairdnerScienceWeek
    02043
  4. Matthias Mann Lab@labs_mann
    Matthias Mann Lab
    RT @GairdnerAwards: Tomorrow: 2026 Gairdner International Symposium Gairdner laureates & leading researchers explore how scientific discoveries move from the lab towards new treatments & shape the future of medicine. 📅 Oct 22, 9AM ET 📍 Toronto & Online 🎟️ Free Register:
    01039
  5. Matthias Mann Lab@labs_mann
    Matthias Mann Lab
    RT @GairdnerAwards: We're pleased to announce the titles for each of the presentations at "After the Gairdner Award—Where Next?", taking place on October 22 as part of #GairdnerScienceWeek 📆 Thursday, October 22 ⏱️ 9:00 AM ET 📍 Toronto & Online 🎟️ Free 🔗 Register: (1/2)
    01053
  6. Matthias Mann Lab@labs_mann
    Can MS-based proteomics see what histology can’t? We profiled 83 rare paediatric adrenocortical tumours from archival FFPE tissue & found 4 proteome-defined states that predict survival better. Now in @eBioMedicine, led by Rainer Claus & Andreas Metousis.
    29342.2K
  7. Matthias Mann Lab@labs_mann
    Posts @labs_mann
    ~8,000 proteins per tumour. The 4 states cut across histology and stratify survival more sharply, a 5-protein classifier reproduces them, and each state shows distinct candidate vulnerabilities. A foundation for proteome-informed precision therapy.
    103500
  8. Matthias Mann Lab@labs_mann
    Posts @labs_mann
    Great collaboration across clinic and lab with Rainer Claus & Michaela Kuhlen (Universitätsklinikum Augsburg), Antje Redlich (Universitätsmedizin Magdeburg), the German MET Registry & co-authors in Giessen, Kiel, Bonn & Munich.
    002391
  9. Matthias Mann Lab@labs_mann
    SPARCS: Deep Visual Proteomics-style laser microdissection meets genome-wide CRISPR screening. Find genes behind how cells look, isolate them, profile them by mass spec. Now in @CellCellPress! Tweetorial from @niklas_a_s follows🧵
    Niklas Schmacke @niklas_a_s
    Out now in @CellCellPress: ✨SPARCS✨, a platform for discovering the genes behind complex cellular phenotypes. SPARCS combines Al-powered image analysis with automated laser microdissection to precisely isolate cells from large mutant libraries. Paper and highlights👇(1/9)
    217737.2K
  10. Niklas Schmacke@niklas_a_s
    Out now in @CellCellPress: ✨SPARCS✨, a platform for discovering the genes behind complex cellular phenotypes. SPARCS combines Al-powered image analysis with automated laser microdissection to precisely isolate cells from large mutant libraries. Paper and highlights👇(1/9)
    Download
    3197814.9K
  12. Matthias Mann Lab@labs_mann
    400,000 citations! 🎉 Matthias Mann @labs_mann just crossed this remarkable milestone on Google Scholar. From electrospray to MaxQuant to Deep Visual Proteomics, he has shaped how the world does proteomics. Congratulations from your team! #Proteomics
    Download
    341085.6K
  13. Matthias Mann Lab@labs_mann
    That's a wrap on #HUPO2026 Singapore! 🎉 Congrats to Katherine Madden (🥇 Poster Competition), Elena Kratz (runner-up) & Kathrin Korff (Thesis Competition runner-up). And to alumni Jesper Olsen, Akhilesh Pandey & Florian Rosenberger, & to Judith Steen, on their HUPO awards! 👏
    Download
    Human Proteome @hupo_org
    Thank you to every speaker who shared their research, every delegate and every partner. This congress would not have been possible without you. Together, we've pushed the field of proteomics forward in ways that will echo well beyond Singapore. See you next year in Italy! #HUPO2026 #Proteomics
    13221.5K
  14. Human Proteome✓@hupo_org
    Thank you to every speaker who shared their research, every delegate and every partner. This congress would not have been possible without you. Together, we've pushed the field of proteomics forward in ways that will echo well beyond Singapore. See you next year in Italy! #HUPO2026 #Proteomics
    Download
    0071.7K
  15. Matthias Mann Lab@labs_mann
    New preprint: with ADAPT-MS, discovery plasma proteomics becomes a diagnostic tool for ovarian cancer. We separate benign from malignant adnexal masses and generalize to 5 validation cohorts. Collaboration with @ErnstLengyel @OvCa_UChicago.
    17181.6K
  16. Matthias Mann Lab@labs_mann
    At #HUPO2026? Come say hi to some of some of our labmates @labs_mann — talks & posters all week on spatial proteomics, plasma biomarkers, a human cell-type proteome atlas, interactomics & AI-driven peptide sequencing. Plenary by Matthias Mann Wed 9:00!
    Download
    23291.7K
  17. Matthias Mann Lab@labs_mann
    Proteomics analysis has always lived in its own universe. AlphaPeptTools puts it in #scverse instead, so that proteome, transcriptome & spatial data sit in one ecosystem. 11 search engines (DDA+DIA) read in, proteomics-specific statistics, #scverse native.
    Download
    3261279.6K
  20. Matthias Mann Lab@labs_mann
    Matthias Mann Lab
    RT @naturemethods: In their Perspective, @labs_mann, Bing Zhang, Tiannan Guo and colleagues discuss key areas in proteomics where AI is poised to drive advances.
    05044
  21. Matthias Mann Lab@labs_mann
    Great job on completing your PhD 🙌. Good luck in Sweden, Max — you will do great!
    Download
    0171K
  22. Matthias Mann Lab@labs_mann
    Same single cell, two modalities—both at depth. We digest protein first, run Smart-seq3xpress + C18 (Evotip) separation: peptides captured, cDNA in flowthrough. In HeLa & stem cells, proteome tracks cell state; RNA variance flags transitioning cells.
    11910910.5K