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Frank Xie lab
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Frank Xie lab

@549nm

Lighting up genome regulation in human development and disease. Views are my own.

273 Following304 Followers242 Posts
  1. Frank Xie lab@549nm
    Frank Xie lab
    RT @Austin_Lefebvre: Do you LOVE organelles?? Well I am THRILLED to announce that Nellie has been published in @naturemethods! Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy 🧵1/N
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  2. Frank Xie lab@549nm
    Frank Xie lab
    RT @naturemethods: In a new Comment, Eric Betzig describes his vision for the future of bioimaging and bioimage analysis. He further recommends "Cell Observatories" as a path forward for addressing complex outstanding biological questions. @Eric_Betzig
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  3. Frank Xie lab@549nm
    Frank Xie lab
    RT @davidrliu: Today in @Science_Magazine we report the laboratory evolution of compact degrons that enable targeted protein degradation triggered by an otherwise-inert small molecule, a multidisciplinary study that integrates organic chemistry, molecular glues, protein evolution, genome editing, and structural biology. PDF: 1/13
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  4. Frank Xie lab@549nm
    Frank Xie lab
    RT @Eric_Betzig: #FluorescenceFriday #Science #neuroscience Dendritic branches (green) in the mouse brain, studded with spines ("lollipops"), and myelin sheaths (pink tubes) that surround axons. Contacts between axons and dendrites called synapses facilitate communication between neurons. There are ~100 trillion synapses in the human brain, so collectively humanity has the same order of synapses as the 10^24 stars estimated in the observable universe. As seen by lattice light sheet expansion microscopy.
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  5. Frank Xie lab@549nm
    Frank Xie lab
    RT @ItaiYanai: How did we lose our tail? A simple question.. but it wasn't really asked before! We discovered a plausible scenario for the genetic mechanism that led to tail loss. Amazing that such a big change may have been caused by such a small genetic event. @BoXia7
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  6. Frank Xie lab@549nm
    Frank Xie lab
    RT @kjaMartens: TARDIS (Temporal Analysis of Relative Distances) is now out in @naturemethods! It redefines single-particle tracking: spt is no longer limited by tracking algorithms - TARDIS offers at least 10x higher throughput, exceptional noise robustness: a 🧵
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  7. Frank Xie lab@549nm
    Frank Xie lab
    RT @NatureRevGenet: Real-time single-molecule imaging of transcriptional regulatory networks in living cells #Review by Dong-Woo Hwang, Anna Maekiniemi, Robert H. Singer & Hanae Sato
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  9. Frank Xie lab@549nm
    Frank Xie lab
    RT @BrahmaComplex: Our paper on RNAPII-BAF-TF synergy is now out in @NatureGenet! Since publishing the preprint (🧵➡️ we added expt to show that enhanced nucleosome eviction upon stabilization of BAF by RNAPII, assayed by CUT&RUN.ChIP, is ATP-dep. ➡️
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  10. Frank Xie lab@549nm
    Frank Xie lab
    RT @JonasRies: We developed an excitation module for 3D multi-color MINFLUX that is simple, stable and cost-effective and will allow for ultra-fast MINFLUX with a high accuracy.
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  11. Frank Xie lab@549nm
    Frank Xie lab
    RT @naturemethods: In case you missed it yesterday! DBlink uses deep learning to capture long-term dependencies between different frames in SMLM data, yielding super-spatiotemporal resolution videos of fast dynamic processes in living cells. @ShechtmanLab
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  12. Frank Xie lab@549nm
    Frank Xie lab
    RT @naturemethods: Out yesterday, a timely piece from Peter Horvath @hpke1980 and colleagues the importance of proper metrics for comparing algorithms for bioimage segmentation and object detection. <!--td {border: 1px solid #cccccc;}br {mso-data-placement:same-cell;}-->
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  13. Frank Xie lab@549nm
    Frank Xie lab
    RT @Stefan_W_Hell: Three-dimensional single-cell transcriptome imaging of thick tissues
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  15. Frank Xie lab@549nm
    Frank Xie lab
    RT @d_brueckner: How do distant DNA loci come into contact to activate genes? Our paper combining live imaging 🔬& polymer physics 🧬 to answer this is out in @ScienceMagazine! We show how chromosome packing & diffusion determine pairwise dynamics & transcription 👉 1/n
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  16. Frank Xie lab@549nm
    Frank Xie lab
    RT @l_masu: ÅNGSTRÖM-RESOLUTION FLUORESCENCE MICROSCOPY. Can we do structural biology with an optical microscope? Yes! Check out how we resolved *single bases of DNA* and much more using fluorescence microscopy, out today in @Nature! @JungmannLab @MPI_Biochem
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  18. Frank Xie lab@549nm
    Frank Xie lab
    RT @NatureBiotech: Enhanced axial resolution for 3D SIM is achieved with deep learning or four-beam interference
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  19. Frank Xie lab@549nm
    Frank Xie lab
    RT @Anders_S_Hansen: (1/n) Our preprint by @JinHarveyYang @hugoresearch is now out in @NatureComms at When a Double-Stand Break (DSB) occurs, how are the two DSB ends brought back together for repair (synapsis)? We suggest a role for loop extrusion!
    Anders Sejr Hansen @Anders_S_Hansen
    (1/n) New preprint by @JinHarveyYang @hugoresearch Q: after a DNA Double-Strand Break (DSB), how are the DSB ends brought back together (synapsis)? Proposal: loop extrusion may 1) prevent DSB ends from diffusing apart and 2) bring them back together.
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  20. Anders Sejr Hansen@Anders_S_Hansen
    (1/n) New preprint by @JinHarveyYang @hugoresearch Q: after a DNA Double-Strand Break (DSB), how are the DSB ends brought back together (synapsis)? Proposal: loop extrusion may 1) prevent DSB ends from diffusing apart and 2) bring them back together.
    Download
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  21. Frank Xie lab@549nm
    I knew we could make it and it does. Congratulations to the team!
    Anastasios Pavlopoulos @TassosAP
    THANK YOU @HFSP!!! It’s official and it’s a dream come true to receive an #HFSPResearchGrants with Frank Xie @549nm and Léo Guignard @GuignardLab to study the developmental regulation of bilateral symmetry. Stay tuned for job ads soon. #ParhyaleRocks
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