Florian Sicklinger@FloSicklinger
Florian Sicklinger
RT @LeuschnerLab: No longer the forgotten valve.
Check out our latest preprint on how tricuspid regurgitation accelerates heart failure.
0201.4K
Florian Sicklinger
@FloSicklinger
Physician-Scientist, investigating innate immunity in cardiovascular disease @uniklinik_hd
333 Following180 Followers39 Posts
- Florian Sicklinger@FloSicklingerUsing the first mouse model of tricuspid valve regurgitation, we identify a cardio-intestinal innate immune circuit in which chronic venous congestion reprograms monocytes into IL-6-producing drivers of heart failure.035253
- Florian Sicklinger@FloSicklingerFlorian SicklingerRT @DucheneJohan: Do we study the right biology after myocardial infarction (MI)? • Surgery in standard mouse model masks MI-specific immune responses • Minimally invasive model better reflects patient immune responses & reveals immature neutrophils worsen heart function0301.1K
- Florian Sicklinger@FloSicklingerFlorian SicklingerRT @HaoYin20: #SpatialOmics #MyocardialInfarction #MolecularCartography 100-gene + #SeqIF 12-marker + #DeepVisualProteomics 4/24/49/96 h postMI🐭 Endocardial vWF mediates Mɸ infiltr Anti-vWF i.v. reduces Mɸ at endocardial, but not epicardial, core or border, zone, but causes infarct wall thinning + worsened cardiac adaptation by 2 wk Cellpose 2 human-in-a-loop for CardioMyocyte segmentation Ankrd1 pixel cluster to demarcate stressed/dying CM Custom analysis pipeline @flowuenne @FloSicklinger @DenisSchapiro @NatureCVR 20250703.4K
- Florian Sicklinger@FloSicklingerFlorian SicklingerRT @rkramann: Please join us for our 2nd Immuno-Cardiology Symposium in beautiful Bar Harbor, Maine, Sept. 18-19! @jacksonlab @MDIBL explore how dysregulated immune system function contributes to inflammation and fibrosis in disease and related disorders in the kidney, lung and liver0903K
- Florian Sicklinger@FloSicklingerFlorian SicklingerRT @CircRes: Sicklinger & colleagues developed a new #ultrasound-guided method to induce #HeartAttacks in mice, allowing precise control & real-time monitoring without the need for invasive surgery. Learn more at @volkersmirko @junedh_amrute @rkramann01503.9K
- Florian Sicklinger@FloSicklingerFlorian SicklingerRT @LeuschnerLab: Check out the latest issue of @CircRes with our Echo-Guided IR Method on the cover ♥️ 🥢Circulation Research @CircRes@CircRes May 9th Issue is Out! Cover: Representative IF staining of endothelial cells (magenta), inflammation (yellow), & WGA (green) in a 4-chamber view of a heart 7 days after Echocardiography-Guided Induction of I/R;nuclei-blue.0601.6K
Circulation Research@CircResPosts @CircRes@CircRes May 9th Issue is Out! Cover: Representative IF staining of endothelial cells (magenta), inflammation (yellow), & WGA (green) in a 4-chamber view of a heart 7 days after Echocardiography-Guided Induction of I/R;nuclei-blue.
0162.7K- Florian Sicklinger@FloSicklingerIn @Circres we describe a novel Echocardiography-Guided Method for Induction of Myocardial Ischemia/Reperfusion. Check out the full study here: Great collaborative effort with @leuschnerlab, @lavinelab, @jacksonlab @rkramann @dzhk_germany @ImmunoFibHF413342.9K
- Florian Sicklinger@FloSicklingerFlorian SicklingerRT @junedh_amrute: In @Nature we use single cell multiomics, fibroblast fate tracing, and in vivo models to characterize immune fibroblast crosstalk in heart failure with @LavineLab @washumedicine, @Amgen , and @ImmunoFibHF060032K
- Florian Sicklinger@FloSicklingerFlorian SicklingerRT @chris_sandmann: Check out our paper just published in Circulation ➡️ Translation controls inflammation after myocardial infarction This work was a huge collaborative effort over many years. @dzhk_germany @DGK_org @VolkersMirko Key findings + paper summary below 🧵⬇️⬇️⬇️040822
- Florian Sicklinger@FloSicklingerFlorian SicklingerRT @VolkersMirko: Very happy that our manuscript is now online @CircAHA. Transient inhibition of translation protects against #reperfusion injury. Kudos to first author @ChrlsHofmann and to all Co-authors for a great team effort. @CRC1550 @dzhk_germany @uniklinik_hd01301.9K
- Florian Sicklinger@FloSicklingerThanks to @BronwynBerkeley for highlighting our method in @NatRevCardiolBronwyn @BronwynBerkeleyRead my Tools of the Trade article, published in @NatRevCardiol, highlighting my experience with and the method of ultrasound guided induction of myocardial infarction: Thanks to @FloSicklinger & F. Leuschner for developing such an innovative method.1423937
Bronwyn@BronwynBerkeleyRead my Tools of the Trade article, published in @NatRevCardiol, highlighting my experience with and the method of ultrasound guided induction of myocardial infarction: Thanks to @FloSicklinger & F. Leuschner for developing such an innovative method.
0181.2K- Florian Sicklinger@FloSicklingerFlorian SicklingerRT @LeuschnerLab: A shortcut to the infarcted heart Excited to share our collaborative effort with @DenisSchapiro lab led by @FloSicklinger and @FloWuenne. Using spatial omics technologies, we found a new way how monocytes sneak into the infarcted heart.0802.3K
- Florian Sicklinger@FloSicklingerFlorian SicklingerRT @DenisSchapiro: I am very excited to share our lab's first preprint @uniklinik_hd together with the @LeuschnerLab. This study was led by @FloWuenne and @FloSicklinger.01807.3K
- Florian Sicklinger@FloSicklingerFlorian SicklingerRT @ImmunoFibHF: 🩵💙🩵💙great symposium - great people - great location!! 🩵💙🩵💙#ImmunoCardiology @jacksonlab #leducq #immunofibHF0605.4K
- Florian Sicklinger@FloSicklingerFlorian SicklingerRT @notimmuneatall: Florian Leuschner Kicking off the first US immunocardiology conference at @jacksonlab. @ImmunoFibHF Very excited about what’s in store the next three days! #CardioTwitter #cardioimmunology0502K
- Florian Sicklinger@FloSicklingerFlorian SicklingerRT @LabWaggoner: von Willebrand factor is upregulated after myocardial infarction and facilitates recruitment of Ccr2+ monocytes that worsen cardiac function @flowuenne @FloSicklinger @DenisSchapiro @NatureCVR @HeidelbergU @uniklinik_hd 🇩🇪0502.5K
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