Waggoner Lab

Altered MAIT cell activation characteristics with impaired IL-10 and IL-17A response programs in active Crohn’s disease @J_Immunol @emouchtaridi @SandbergLabKI @C_Boulouis @karolinskainst 🇸🇪

An in vivo T cell engager platform induces deep plasma cell depletion in autoimmune dry eye @CellRepMed

PhIP-Seq reveals geography- and disease-associated human herpesvirus antibody repertoires and distinct EBV response modules @CellReports

IFN-γ and proinflammatory cytokines induce astrocyte programs that support antigen-dependent CD4+ T cell restimulation @CellReports @LiddelowSA @nyulangone @borderbiologist

Arginine rewires eIF4F translation initiation to overcome fever-induced CAR T cell dysfunction @Cell_Metabolism @NIH

TFXcan, a framework that predicts personalized transcription factor binding from genotype data across ∼700 transcription-factor-tissue pairs @CellGenomics @hakyim @TAmariuta @UChicago @UCSDnews

PD-L1 on B cell zone reticular cells, including follicular dendritic cells, promotes humoral immunity by restraining a subset of Tfh that promotes Tfr development @ImmunityCP @eakamagarren @BostonChildrens

Efficacy of PD-L1×4-1BB antibodies relies on PD-L1+ cDC1, which integrate antigen cross-presentation, IL-12, & 4-1BB costimulation to promote efficacious T cell-mediated antitumor immunity @ImmunityCP @DrIgMelero @ClinicaNavarra @Teijeira_ITLive 🇪🇸

Vanin-pantethine-cholesterol axis acts as a metabolic checkpoint controlling dendritic cell activation in autoimmune inflammation @JExpMed

Cbfβ/Runx complex is a direct driver for preferential IL-13 expression by binding the Il13 promoter and promoting chromatin accessibility and enhancer-promoter interactions without affecting GATA3 expression @JExpMed

Congrats @LukensJohnR @Addie_E_Walsh Alzheimer’s genetic risk factor CASS4 controls microglial focal adhesion biology and amyloidosis @JExpMed @UVA

RT @CincyResearch: Cincinnati Children's researchers linked blood protein patterns to stomach changes in eosinophilic gastritis, offering clues for future disease monitoring. Published in @jacionline. Learn more: #PediatricResearch #ChildHealth #CincyResearch

Existing antibodies that increase dengue virus replication are associated with acute inflammation and limited development of protective immunity @ScienceTM

CHI3L2 disrupts phospholipid balance in psoriatic keratinocytes via an autocrine loop with therapeutic intervention potential @ScienceTM

Brain-sensing synNotch–CAR T cells exhibit efficacy against preclinical models of diffuse midline glioma, outperforming conventional CAR T cells @ScienceTM @UCSF

CCR8xCD3 bispecific antibody potently boosts antitumor immunity by engaging T cells for the depletion of immunosuppressive intratumoral Treg cells @ScienceTM @genentech

CD74 governs synovial macrophage glycolytic-inflammatory synergy by an ENO2–HIF-1α/β-catenin axis to drive osteoarthritis progression @ScienceTM

B cell subsets contribute to long-term tumor control and improved overall patient survival in multiple tumor types @ScienceTM @UCSDnews

Review @ScienceTM Acute kidney injury as a systemic disease

RT @LabBarisic: Beyond thrilled that the first paper from our lab is out today in @nature! We show that SWI/SNF loss results in gain-of-function for CTCF and cohesin, reshaping the 3D genome, and an unexpected switch between chromatin remodeling complexes. 1/n