Immunity

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RT @LabWaggoner: Efficacy of PD-L1×4-1BB antibodies relies on PD-L1+ cDC1, which integrate antigen cross-presentation, IL-12, & 4-1BB costimulation to promote efficacious T cell-mediated antitumor immunity @ImmunityCP @DrIgMelero @ClinicaNavarra @Teijeira_ITLive 🇪🇸

RT @LabWaggoner: PD-L1 on B cell zone reticular cells, including follicular dendritic cells, promotes humoral immunity by restraining a subset of Tfh that promotes Tfr development @ImmunityCP @eakamagarren @BostonChildrens

Online now: T cell cross-priming by PD-L1+ type 1 conventional dendritic cells mediates the antitumor efficacy of a PD-L1×4-1BB bispecific antibody dlvr.​it/TW5dCV

Online now: PD-L1 expression in germinal centers promotes humoral immunity by restricting T follicular regulatory cell differentiation dlvr.​it/TW5W2b

Hear from keynotes Ardem Patapoutian @ardemp @scrippsresearch & Gloria Choi @MIT at #CPSNeuroImmune27 in New York @NYAMNYC and share your own research with the neuroimmunology community. Abstract deadline: April 30, 2027

Online now: A microbiome-reactive TMIGD2hi Th17 subset is spatially enriched at the intestinal epithelium and expanded in inflammatory bowel disease dlvr.​it/TW48GH

Online now: Human brain cellular xenografts in neuroimmunology and beyond dlvr.​it/TW4233

Online now: NF-κB phosphorylation controls enhancer selection to shape the inflammatory gene program dlvr.​it/TW2L64

RT @TheDoctorNews: Why Some People Age Like Fine Wine CD8 cells in the immune system appear to reflect how healthy one's old age will likely be and could lead to a diagnostic test of aging. #Aging #agingwell #immunity @ImmunityCP #immunehealth #inflammation #Granzymes #CD8

RT @sokol_mdphd: Why does it take repeated exposures to become allergic, and why does one allergy lead to others? I talked with Claudia Hammond on BBC Health Check about our new @ImmunityCP paper: sensory neurons in mice remember allergen exposure. 🎧

RT @LukensJohnR: Embracing macrophage complexity for research and translation. @ImmunityCP

RT @EricTopol: Spotlighting the macrophage cells in our blood and tissue, their role in diseases, and targeted interventions @ImmunityCP

RT @IdoAmitLab: What comes after M1/M2? In our Perspective with @FGinhoux in @ImmunityCP we explore how single-cell technologies and AI can decode the gene programs macrophages use across tissues & microenvironments, and how this modular view could transform immunotherapy

RT @ExtracellMatrix: This @ImmunityCP study found that #microglia exhibited acute and progressive morphological responses that preceded but paralleled ethanol-induced sedation. 📖 First authors Evi Paouri and Sarah Stanko show that genetic deletion of microglial Myd88 protect against ethanol-induced microglial reactivity, neuronal damage and dysfunction, intoxication, and motor impairments by preventing #ECM disruption.

Online now: Embracing macrophage complexity for research and translation dlvr.​it/TVxZsp

Online now: Lactate dehydrogenase A-dependent redox control of selective mRNA translation directs monocyte fate commitment dlvr.​it/TVwwlg

Online now: Dan Kastner (1951–2026) dlvr.​it/TVwpWt

RT @ExtracellMatrix: Using temporal multi-omics, biomechanical profiling, and spatial fate mapping in #colitis models, @WeizmannScience researchers showed that colonic #ECM underwent lasting pathological reprogramming following inflammation. 🔎 Their findings, published in @ImmunityCP, redefine the ECM as a long-lived instructive compartment that encodes injury memory and promotes maladaptive regeneration.

RT @Tsinghua_Uni: Can our immune system remember a virus for 20 years? Prof. Zhang Linqi’s Innovative Tsinghua team @MedTsinghua found that SARS-CoV-1 immune memory can endure for two decades in @ImmunityCP, providing new insights for broader vaccines with @HKUniversity and other collaborators.

RT @EricTopol: Unraveling the immune system's role in our healthspan Breaking down a seminal study just published @ImmunityCP