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LechtenbergLab

@LechtenbergLab

News and updates from the Lechtenberg Lab at WEHI in Melbourne. Interested in Ubiquitin ligases, protein structures, and drug discovery. Views my own.

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  1. LechtenbergLab@LechtenbergLab
    Excited to share our latest preprint on @biorxivpreprint: "The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro".
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  2. LechtenbergLab@LechtenbergLab
    We are still accepting abstracts for selected short talks and posters. The abstract deadline has been extended to this Friday, 1st Aug. More information and registration here: .
    LechtenbergLab @LechtenbergLab
    📣📣 Lorne Ubiquitin – The Australian Ubiquitin Summit 📣📣 20-23 Nov 2025 in Lorne, Australia Join us this Nov for the first ubiquitin meeting in Australia. Submit your abstract by 18 July 2025 for oral and poster presentations: Please share and repost.
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  3. LechtenbergLab@LechtenbergLab
    📣📣 Lorne Ubiquitin – The Australian Ubiquitin Summit 📣📣 20-23 Nov 2025 in Lorne, Australia Join us this Nov for the first ubiquitin meeting in Australia. Submit your abstract by 18 July 2025 for oral and poster presentations: Please share and repost.
    Download
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  4. LechtenbergLab@LechtenbergLab
    LechtenbergLab
    RT @Rashmi_Agrata: Australia’s First Ubiquitin Summit is here! 🥳 📍Lorne, Victoria | 🗓️ 20–23 November 2025 Join us on the scenic coastline of Lorne for 4 days of cutting-edge ubiquitin science, featuring a fantastic lineup of international speakers covering all corners of the ubiquitin world
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  5. LechtenbergLab@LechtenbergLab
    LechtenbergLab
    RT @LazarouLab: Join us in Lorne for the 11th ISA. We have a fantastic line up of speakers at a beautiful coastal location in Australia. Hope to see you there!
    Thanh (Ricky) Nguyen @ThanhNguyen_TNN
    Michael Lazarou and I will be chairing the 11th International Symposium on Autophagy (ISA) in Australia from 16-20 Nov 2025! 📍 Location: Lorne, Victoria, Australia 🌐 Register now: Join us for five inspiring days of cutting-edge autophagy research!
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  6. Thanh (Ricky) Nguyen@ThanhNguyen_TNN
    Michael Lazarou and I will be chairing the 11th International Symposium on Autophagy (ISA) in Australia from 16-20 Nov 2025! 📍 Location: Lorne, Victoria, Australia 🌐 Register now: Join us for five inspiring days of cutting-edge autophagy research!
    Download
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  7. LechtenbergLab@LechtenbergLab
    Excited to share our latest work, now out in @LSAjournal. We show that the E3 ligase HOIL-1 can ubiquitinate many different saccharides and describe a chemoenzymatic platform to generate ubiquitinated sugars as tools for studying non-proteinaceous ubiquitination.
    LifeScienceAlliance @LSAjournal
    The RBR E3 ligase HOIL-1 ubiquitinates Ser/Thr-residues and various disaccharides in vitro and can be used to generate ubiquitinated sugars as tools to study non-proteinaceous ubiquitination @LechtenbergLab @WEHI_research
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  8. LifeScienceAlliance@LSAjournal
    The RBR E3 ligase HOIL-1 ubiquitinates Ser/Thr-residues and various disaccharides in vitro and can be used to generate ubiquitinated sugars as tools to study non-proteinaceous ubiquitination @LechtenbergLab @WEHI_research
    Download
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  9. LechtenbergLab@LechtenbergLab
    Posts @LechtenbergLab
    We hope this will be useful for the field. A plasmid for expressing the constitutively active HOIL-1 variant is available via @Addgene:
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  10. LechtenbergLab@LechtenbergLab
    LechtenbergLab
    RT @WEHI_research: World-first: researchers have discovered what protein #PINK1 looks like in humans and how it is activated, solving a decades-long mystery in the fight against #Parkinsonsdisease. The team hope to use the knowledge to find a drug to stop #Parkinsons.
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  13. LechtenbergLab@LechtenbergLab
    LechtenbergLab
    RT @MolecularCell: Online Now: Combinatorial mapping of E3 ubiquitin ligases to their target substrates
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  14. LechtenbergLab@LechtenbergLab
    For those wanting to try to ubiquitinating sugars themselves: our plasmid for bacterial expression of the constitutive HOIL-1 variant is now available via Addgene:
    LechtenbergLab @LechtenbergLab
    Excited to share our latest preprint on @biorxivpreprint: "The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro".
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  15. LechtenbergLab@LechtenbergLab
    LechtenbergLab
    RT @DrClareWeeden: I am looking for a research assistant to join my new lab in Melbourne, Australia at WEHI. Please apply at the link below!
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  16. LechtenbergLab@LechtenbergLab
    LechtenbergLab
    RT @WEHI_research: Just announced by WEHI, Sir Gus and the Nossal family: the Sir Gustav Nossal Professor of Immunology. This prestigious new position will lead pivotal research to advance human immunology. Made possible by a generous gift from the Nossal family. Read more:
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  17. LechtenbergLab@LechtenbergLab
    Posts @LechtenbergLab
    We hope that our protocol will enable us and others to generate various ubiquitinated saccharides as tools to further develop the non-proteinaceous ubiquitin field. A plasmid for bacterial expression of the HOIL-1 variant will be available at @Addgene soon.
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  20. LechtenbergLab@LechtenbergLab
    LechtenbergLab
    RT @WEHI_research: Interested in Honours, Masters, or PhD studies in medical research? We have over 70 student research projects starting in 2025, across the breadth of research areas at WEHI. Explore the opportunities here: #WEHIStudents #StudyInMelbourne #UniMelb
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