#SingleCell

How tissue dissociation impacts scRNA-seq: Standard protocols can lose reactive astrocytes & key pathological signatures! 🧠 Check out our new paper in Molecular Neurobiology on optimized workflows: #SingleCell #Neuroscience #Astrocytes

Are blood samples haunting your lab? Find out what’s reality and what’s just a scary story with our version of Trick or Treat. First up: Blood has to reach a lab within 2 hours for #SingleCell processing. Trick or treat? Learn more >

You’ve clustered and annotated your cells. But what’s regulating their state? Find the biology your #singlecell transcriptome data is missing. GEM-X Epi Multiome has the answers. Join the webinar to learn how to get started:

Epigenetics Update - A temporal single cell atlas of dynamic chromatin accessibility during murine lung maturation #Epigenetics #SingleCell #Chromatin #Lung --- Gain deeper insights into gene regulation;

👏 Enormous thanks go to our sponsors and partners: @UniversityRudn Yandex Cloud and SingleCell LLC ( #bioinformatics #hackathon #singlecell #AI #ASCA

Hackatomics 2026 results Wet lab researchers, bioinformaticians, and AI specialists joined forces to create innovative approaches in precision medicine based on single-cell data. More details: #ASCAinfo #SingleCell #SpatialBiology

I used gganimate in #Rstats to tell a story about #singlecell #spatialtranscriptomics #bioinformatics #dataanalysis Code: If a picture is worth a 1000 words, perhaps an animation is worth a million? What's your interpretation of this #dataviz story?

What gets erased when you integrate #singlecell data across samples/studies, and can you get it back? When samples are from e.g. healthy & disease, should you simply massage cells together? FINALLY, I feel we can answer this question:

🧬 Discover how single-cell ATAC-seq reveals chromatin accessibility and gene regulation at the cellular level. Join our 4-Day Hands-On Workshop on Single-Cell ATAC-Seq & Multiome Data Analysis

Learn QC, RNA+ATAC integration, motif analysis, and gene regulatory network inference using a B-cell lymphoma case study. 🔗 #SingleCell #ATACSeq #Multiome

Applications are now open for our Single Cell Explorer Research Grant Program designed for researchers who are new to Parse Biosciences! Learn more and apply: #singlecell #researchgrant

Very excited to announce our cell-type resolved #zebrafish enhancer map based on #singlecell #ATACseq (#sciATAC) data! Great work by @McgarveyAlison @WolfgangKopp3 @dusa_dv and more, led by @slacadie. Thanks to all our colleagues that made this possible!!

Excited to share our #MultiRegion #SingleCell dissection of #Alzheimers out in @Nature today studying #Reelin in #RegionSpecific #NeuronalVulnerability, #CholineMetabolism and #PolyAmineBiosynthesis in #CognitiveResilience, #Astrocyte diversity, #Thalamus-specific #Interneurons, #scDemon for #Module analysis, and so much more. Paper: News: Website/Data: Interactive website: Cell Browser: Code: scDemon module analysis: with: @Carles_Boix, @MathysHansruedi, @Leyla_Aakay, @DrLiHueiTsai, #DavidBennett, @RudyTanzi, @__ben_james__, @_JoseDavila, #KikiGalani, @NeilBBand, @NIHAging, #CureAlz and so many more amazing contributors. Truly grateful for an amazing team and collaboration #OpenAccess #OpenScience #NeuroDegeneration

As promised, the tweetorial for our fresh off-the-press work: "Single cell tracing unveils role for TCF15 in haematopoiesis" #bonemarrowtransplantation #hematology #SingleCell #stemcell

If this was a game of "Made You Look at Mitochondria", I would be winning... #Microscopy #CellBiology #SingleCell

Epigenetics Update - Deep dynamical models of single-cell multiomic velocities predict loss-of-function and rescue perturbations in B cells @LabBarisic and Christina Leslie in @NatureBiotech #Epigenetics #SingleCell ---

1/ Exciting news! We just released a preprint on a new single-cell technology, ME-seq, that maps DNA methylation, gene expression & chromatin accessibility—all in the same cell, at scale. And yes, it’s a LOT cheaper 🤑than current methods! 🧬 #SingleCell #Epigenetics

Our first #bioRxiv! ACME: We provide a novel dissociation approach for #SingleCell RNA-seq. Cells are fixed from start, can be frozen multiple times, labelled and sorted. With this, we profile ~34K planarian cells using SPLiT-seq. A twetorial : 1/N

👻 The scariest thing in single-cell biology? Missing what happens next. 👇

2/ Traditional #singlecell methods provide powerful molecular snapshots. But when measuring a cell requires sacrificing it, its story ends there. What happens after treatment? How does the cell respond over time? With conventional destructive single-cell methods, these changes often have to be inferred from different cells rather than directly observed in the same living cell.

Online now! Stereo-seq combines DNA nanoball patterned arrays and tissue RNA capture to achieve large field-of-view spatial transcriptomics at cellular resolution! #sciencetwitter #singlecell

Immensely proud to share our four papers on #SingleCell dissection of #Alzheimers Disease coming out in @CellCellPress today, reporting 2.3M #scRNA profiles and 850k #scATAC profiles across 427 post-mortem human brain samples from AD and non-AD donors in a wonderful #interdisciplinary collaboration with @DrLiHueiTsai between @MIT @MIT_Picower @MIT_CSAIL @BroadInstitute @RushUniversity Paper 1: scRNA + vulnerability + resilience Paper 2: scATAC + GWAS + Epigenome Erosion Paper 3: Microglia States + reprogramming Paper 4: DNA damage + gene fusions MIT News: Issue: News & Views:

Just for fun, I use animation to visualize #RNAvelocity with moving arrows on our VeloViz embedding of #singlecell pancreas endocrinogenesis #scRNAseq data with missing intermediate cell states Code: #RStats #BioInformatics #dataviz #bioviz #codetutorial