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Posts with #CacheChallenge

#CacheChallenge

Public posts on X that use #CacheChallenge.

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  1. Foldit@Foldit
    We're taking on SARS-CoV-2 with a series of new design puzzles. Can you help stop the viral helicase? 🧬 Learn more in this month's Lab Report: 📽️ #CacheChallenge #CitizenScience
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    0912
  2. Conscience@consciencemeds
    #CACHEChallenge 5 is now live! Predict antagonists for the MCHR1 protein. No protein structure known for MCHR1, only ligands, so participants will really have to put their algorithms to the test. Find out more and apply: #DrugDiscovery #AI #OpenScience
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  4. 叢雲くすり (創薬ちゃん)@souyakuchan
    #CACHEChallenge 第５シーズンが来た。 標的は Melanin-concentrating hormone receptor 1 (MCHR1)、既にリガンドは複数知られているが実測構造は解かれていない GPCR。中枢神経系の一次繊毛に発現しており摂食や情動などに寄与しているらしい。
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    Structural Genomics Consortium (SGC) @thesgconline
    The new #CACHEChallenge has officially been released. Computational chemists, #AI-savvy scientists from academia, biotech, and pharma take advantage of this chance and apply today if you think you can predict novel antagonists for MCHR1!
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  5. Structural Genomics Consortium (SGC)@thesgconline
    The new #CACHEChallenge has officially been released. Computational chemists, #AI-savvy scientists from academia, biotech, and pharma take advantage of this chance and apply today if you think you can predict novel antagonists for MCHR1!
    Matthieu Schapira @mattschap
    Announcing the 5th CACHE challenge. Predict novel antagonists for MCHR1, a GPCR with no structure in the PDB but hundreds of known ligands... Compounds will be tested in Bryan Roth @zenbrainest lab at UNC and results published. Apply by Feb 14th. #compchem
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  6. 叢雲くすり (創薬ちゃん)@souyakuchan
    Critical Assessment of Computational Hit-finding Experiments (CACHE) というネーミングからして創薬版 CASP (Critical Assessment of Techniques for Protein Structure Prediction) であると分かるコンペティション。 みんなもエントリーしただろうか？ #CacheChallenge
    Structural Genomics Consortium (SGC) @thesgconline
    The first CACHE Challenge ends Jan. 31, 2022! Let's do this, the target is #LRRK2. Download & submit your application before it's too late! #CacheChallenge #DrugDiscovery #Target2035 #OpenScience #ParkinsonsDisease
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  8. Conscience@consciencemeds
    Congratulations to the CMU-UBC team for their top-notch work in our first #CACHEChallenge! You can hear from @olexandr himself about their methods at the #CACHESymposium, March 6-7 in Toronto. Register here:
    Olexandr Isayev 🇺🇦🇺🇸 @olexandr
    Little write-up for our CMU-UBC team competing (and winning 🏆 ) for CACHE #1 challenge! Finding small molecule hits with #compchem methods for a challenging LRRK2 WDR domain. #drugdiscovery
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  10. Matthieu Schapira@mattschap
    Announcing the 5th CACHE challenge. Predict novel antagonists for MCHR1, a GPCR with no structure in the PDB but hundreds of known ligands... Compounds will be tested in Bryan Roth @zenbrainest lab at UNC and results published. Apply by Feb 14th. #compchem
    Download
    110425.6K
  13. Conscience@consciencemeds
    More coverage of the results from #CACHEChallenge 1, released last week. This one with some great quotes from @olexandr, who teamed up with @MKCMU and Artem Cherkasov at @VanProstateCtr to submit one of the top-scoring predictions. He's also speaking 👇
    1691.5K
  17. Sergei Yakneen@SergeiIakhnin
    I started a new adventure, as CTO of @IsomorphicLabs, working with @demishassabis and an all-star team! Building on breakthroughs like AlphaFold from @DeepMind, we will reimagine drug discovery from first principles with AI. I am hiring top talent in ML, product, and engineering!
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  18. Structural Genomics Consortium (SGC)@thesgconline
    Big shoutout to the SGC @UofT team for screening 1739 compounds. As CACHE's experimental arm, we're sharing all binders, screening data, and structures of experimentally tested compounds openly, free from IP restrictions. #OpenScience #DrugDiscovery #CACHEChallenge #SARSCoV2
    Matthieu Schapira @mattschap
    Experimental testing of 1739 compounds predicted by 23 CACHE #3 participants to bind the Macro domain of SARS-CoV-2 NSP3 is out. 28 compounds selected by 9 participants were confirmed and advanced to the hit-expansion round. #compchem @thesgconline
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  19. Matthieu Schapira@mattschap
    Experimental testing of 1739 compounds predicted by 23 CACHE #3 participants to bind the Macro domain of SARS-CoV-2 NSP3 is out. 28 compounds selected by 9 participants were confirmed and advanced to the hit-expansion round. #compchem @thesgconline
    Download
    02153.8K
  23. Karla Rivera@KarlaRiveraMX
    Llega el #CacheChallenge , que consiste en recoger basura y depositarla en su lugar 🌎🙌 ¡Más retos como este! 🚮 🇲🇽 👏
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    17296512
  25. 叢雲くすり (創薬ちゃん)@souyakuchan
    It is inherently difficult to find the "best" method that can be applied to everything, because the optimal method varies depending on the target. As it relates to the concept of #CACHEChallenge, I think the starting point should be to try various methods to get hit compounds.
    Bob the Grumpy Med Chemist @med_chemist
    The differences in what I thought my neural intelligence machine (brain) was doing and the real world performance are well demonstrated by the damn awful grammar below... "benchmark" not "benchmarking"
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  26. Bob the Grumpy Med Chemist@med_chemist
    The differences in what I thought my neural intelligence machine (brain) was doing and the real world performance are well demonstrated by the damn awful grammar below... "benchmark" not "benchmarking"
    000
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